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Lifestyle affects risk of second breast cancer

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Lifestyle affects risk of second breast cancer

Surviving breast cancer is no guarantee that a new cancer won’t appear in the other breast. However, research now suggests that women can build their own personal armor to at least partially protect themselves from this occurring.

All it takes, says Dr. Christopher I. Li, is to “stay at a normal weight, don’t smoke, and drink in moderation.”

The research, headed up by Li at the Fred Hutchinson Cancer Center in Seattle, Washington, suggests that obesity, smoking and drinking too much are all risk factors for breast cancer in the opposite breast — also called the “contralateral” breast — of women who’ve had an “estrogen receptor-positive invasive breast cancer.”

That’s because estrogen can fuel these tumors’ growth, and both fat tissue and excessive alcohol use directly increase estrogen levels in the body, Li and his team propose. They believe that smoking contributes to the risk because of all the cancer-causing substances one inhales when smoking.

Until now, there haven’t been many studies regarding ways that women could protect themselves from second breast cancers, according to the report in the September 8th online issue of the Journal of Clinical Oncology.

The new study included 365 women with a first estrogen receptor-positive breast cancer and a second contralateral cancer and 726 control subjects. By reviewing medical charts and interviewing the women directly, the researchers determined body mass index (BMI) and alcohol and tobacco use. BMI is an estimate of a person’s relative body fat calculated from her height and weight.

Compared with normal weight women, those who were obese were almost half again – by 40% — as likely to develop a contralateral breast cancer. Consumption of 7 or more alcoholic drinks per week nearly doubled the risk compared with no alcohol use. Findings were similar for current smoking.

Women who both smoke and drink following diagnosis of the first cancer had an even greater risk of a second cancer. The study showed that consuming 7 or more alcoholic drinks per week coupled with current smoking increased the odds of contralateral breast cancer more than 7-fold.

In a related editorial, Dr. Jennifer A. Ligibel, from the Dana-Farber Cancer Institute in Boston, points out that the study by Li and his team took place before use of hormonal therapy for estrogen receptor-positive breast cancer became routine. Therefore, a more modern study examining the effect of modifiable lifestyle factors should involve patients treated according to current guidelines.

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Only 10 percent of U.S. adults have low heart risk

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Only 10 percent of U.S. adults have low heart risk

Ninety percent of American adults have at least one risk factor for heart disease, researchers reported on Monday.

Virtually all Americans either have high blood pressure, high cholesterol, high blood sugar, are overweight, smoke or exercise too little, the team led by the Centers for Disease Control and Prevention reported.

“Unfortunately, the limited strides that were made toward this goal during the 1970s and 1980s were eroded by the increases in excess weight, diabetes and hypertension during more recent decades,” the CDC’s Dr. Earl Ford, who led the study, said in a statement.

Ford’s team looked at four national studies covering tens of thousands of Americans aged 25 to 74.

Only 10 percent had low risk scores in all five categories, they reported in the journal Circulation.

“Until the early 90s, we were moving in a positive direction, but then it took a turn and we’re headed in a negative direction,” said Ford.

“When you look at the individual factors, tobacco use is still headed in the right direction and so are cholesterol levels, although that has leveled off. The problem is that blood pressure, BMI (body mass index, a measure of obesity) and diabetes are all headed in the wrong direction.”

Heart disease is the No. 1 killer in the United States and many other countries.

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Overweight mothers linked to infant heart defects

Overweight mothers linked to infant heart defects

Women who are overweight or obese when they get pregnant are more likely to give birth to children with congenital heart defects, according to a U.S. government study released on Thursday.

The study, conducted by the U.S. Centers for Disease Control and Prevention, concluded that women who were overweight or obese at the time they became pregnant were 18 percent more likely to give birth to babies with heart defects, while severely obese women had a 30 percent increased risk.

The babies had problems including obstructive defects on the right side of the heart and defects in the tissue separating the heart’s two upper chambers, the researchers reported in the American Journal of Obstetrics and Gynecology.

“Congenital heart defects are the most common types of birth defect, and among all birth defects, they are a leading cause of illness, death and medical expenditures,” said Dr. Edwin Trevathan, a CDC expert on birth defects and developmental disabilities.

The CDC, the U.S. government’s disease watchdog, recommends that overweight women work with their doctors to achieve a healthy weight before pregnancy.

Researchers examined the health of 6,440 infants with congenital heart defects and 5,673 infants without problems, all of whose mothers were interviewed as part of the CDC’s National Birth Defects Prevention Study.

They assessed obesity according to each woman’s body mass index, or BMI, which relates weight to height. A woman 5 feet, 5 inches tall and weighing 190 pounds (86 kg) would have a BMI of 31.6, while a woman of the same height who weighs 160 pounds (72 kg) would have a BMI of 26.6.

The researchers defined overweight as a BMI of 25 to 29.9, moderate obesity as a BMI of 30 to 34.9 and severe obesity as a BMI of 35 or above.

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