Tag Archives: risk

For women on HRT, tenderness may be warning sign

July 11, 2012Uncategorizedand, archives of internal medicine, be, beating, bf1, blister, breast, breast cancer, breast cancer risk, breast exams, breast tenderness, california los angeles, calories, Choreography for Weight Health Story, colleagues, diet, dr carolyn, Drug, eating, estrogen plus progestin, Exercise, Flu, for, gallery, Gym, Health Health, health initiative, Health Latest, health video, history, hormone replacement therapy, HRT, in, laparoscopy, Malaysia Health, mammograms, may, medical, menopausal women, menopause, menopause symptoms, Nutrition, of, on, operation, organic, photo, physical, premarin, prempro, researchers, risk, risk for breast cancer, skin, spiritual, study, Surgery, symptoms, tips, to, training, university of california los angeles, video, video photo, video surgery, virus, warning sign, web Health, web Health picture, weightloss, WHI, whi study, women, women Picture, women Web, women for Weight gallery, women for Weight Health photo, women Gallery, women over Picture, women Photo Gallery, women Asia, women Health History, women Health Photo, women Video, women Health, women Health Information, women Health Latestazuan

For women on HRT, tenderness may be warning sign

Women whose breasts became tender after taking hormone replacement therapy had nearly twice the risk of developing breast cancer than women whose breasts did not become tender on the drugs, U.S. researchers said on Monday.

They said breast tenderness may be a way to identify women who have a higher risk of developing breast cancer while taking hormone replacement therapy to treat menopause.

“We report that an increase in breast tenderness, easily detected by physicians or patients, identifies a population at particular risk for breast cancer,” Dr. Carolyn Crandall of the University of California Los Angeles and colleagues reported in the Archives of Internal Medicine.

The team analyzed data on the more than 16,000 women who took estrogen-plus-progestin as part of the widely publicized Women’s Health Initiative or WHI study, which was halted in 2002 when researchers found healthy menopausal women who took the drugs were more likely to develop breast cancer.

Most of the women in the WHI studies took Premarin or Prempro made by Wyeth.

Doctors now recommend hormone replacement therapy for women suffering severe menopause symptoms, but caution that they should use the lowest dose possible for the shortest period of time.

Crandall and colleagues culled through the data to see if breast tenderness played a role in breast cancer risk. In the study, 8,506 took estrogen plus progestin and 8,102 got placebo pills.

The women had mammograms and breast exams at the start of the trial and every year after that. They reported whether they had breast tenderness at the beginning of the trial and a year later.

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Breast defence

July 9, 2012Uncategorizedabnormal growth, and, beating, bf1, birth control pills, blister, brca1 and brca2, brca1 and brca2 genes, breast, breast cancer, breast cancer causes, breast cancer increases, breast cancers, Breast defence, Breast defence Asia, Breast defence for Weight Health Story, Breast defence for Weight gallery, Breast defence for Weight Health photo, Breast defence Gallery, Breast defence Health, Breast defence Health History, Breast defence Health Information, Breast defence Health Latest, Breast defence Health Photo, Breast defence over Picture, Breast defence Video, Breast defence Web, Breast defence Photo Gallery, Breast defence Picture, breast tissue, calories, canadian women, Cancer, dense, diet, Drug, eating, estrogen production, Exercise, fat cells, Flu, for, gallery, genes, genetic mutations, genetic problems, genetic vulnerabilities, Gym, Health Health, health video, history, history of ovarian cancer, hormone replacement therapy, in, is, laparoscopy, lifestyle factors, Malaysia Health, medical, menopausal women, Nutrition, of, one, operation, organic, ovarian cancer, photo, physical, picture, post menopausal, radiation therapy, risk, skin, spiritual, Surgery, symptoms, The, tips, to, training, video, video photo, video surgery, virus, web, web Health, web Health picture, weightloss, woman, womenazuan

Breast defence

Some women have specific genetic problems but those breast cancers number less than 10% of all. One expert recently told me that breast cancer causes are “multifactorial” and that the combination of lifestyle factors and genetic vulnerabilities that accounts for the abnormal growth of cells is still being figured out.

That means that most of the 22,700 Canadian women (and 180 men) expected to be diagnosed this year won’t even know what caused their illness. Neither will the 5,400 women who die from it. Sometimes we forget just how many different factors may contribute to breast cancer’s development. Here’s what’s known:

ESTROGEN

The more estrogen a woman makes over time or takes through post-menopausal combined hormone replacement therapy, the higher her risk for getting breast cancer. The more years a woman menstruates, the longer breast tissue is estrogen-exposed. Birth control pills only slightly increase risk.

AGE

The chance of getting breast cancer increases as a woman ages. According to Dr. Love, from 20 to 30 the risk is one in 2,000; from 40 to 49 the risk is one in 68; from 60 to 69 the risk is one in 26. After the age of 70, a woman has a one-in-eight chance of getting breast cancer.

ALCOHOL

The risk of breast cancer jumped by 30% in women who drank more than three drinks daily.

FAMILY HISTORY

Having a mother, sister or daughter with breast cancer almost doubles a woman’s risk, particularly if the relative was diagnosed before age 50. A family history of ovarian cancer also increases the risk of developing breast cancer.

RADIATION

Radiation therapy for a previous cancer heightens the risk of breast cancer. The risk is highest if there was chest radiation during puberty.

OBESITY

Post-menopausal women who are obese are more at risk; fat cells play a role in estrogen production so being overweight adds to risky estrogen exposure.

GENETIC MUTATIONS

Those who have inherited changes in the BRCA1 and BRCA2 genes have a higher risk (some up to 90%) of getting the disease, and possibly at a younger age. Many other genes are also associated with breast cancer, including the HER-2/neu oncogene.

ENVIRONMENT

We’re exposed to vast amounts of hormone-mimicking and cell-interrupting chemicals in products we use and through environmental pollutants, some of which increases the risk of breast cancer.

BREAST DENSITY

Dense breast tissue, as shown on a mammogram, increases your risk. One study published in the Journal of the National Cancer Institute found that the relative risk of developing breast cancer in post-menopausal women with dense breasts was 400% higher than in women with fatty non-dense breasts.

BREAST DISEASE

Some diseases, including hyperplasia, can increase breast cancer risk by up to four-fold.

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Antioxidants may raise diabetes risk: study

July 4, 2012Uncategorizedan, and, antioxidants, Antioxidants Gallery, Antioxidants Photo Gallery, Antioxidants Asia, Antioxidants for Weight gallery, Antioxidants Health, Antioxidants Health History, Antioxidants Health Information, Antioxidants Health Latest, Antioxidants Health Photo, Antioxidants Picture, Antioxidants Video, Antioxidants Web, Antioxidantsfor Weight Health photo, Antioxidantsover Picture, Antioxidantsvideo, be, beating, bf1, blister, body, calories, Cancer, Choreography for Weight Health Story, diabetes, diabetes risk, diet, Drug, eating, Exercise, Flu, for, gallery, Gym, Health Health, Health Latest, health video, history, in, insulin, laparoscopy, Malaysia Health, may, medical, mice, Nutrition, of, operation, organic, photo, physical, picture, prevent, risk, risk study, skin, spiritual, stress, study, Surgery, symptoms, tips, to, training, type 2 diabetes, video, video photo, video surgery, virus, web Health, web Health picture, weightlossazuan

Antioxidants may raise diabetes risk: study

Instead of protecting against diabetes, antioxidants — compounds in foods and supplements that prevent cell damage — may actually increase the chances of getting diabetes, at least in the early stages, Australian researchers reported on Tuesday.

“In the case of early type 2 diabetes … our studies suggest that antioxidants would be bad for you,” Tony Tiganis of Monash University in Australia, whose study appears in the journal Cell Metabolism, said in a statement.

Antioxidants are protective proteins that can prevent cell damage caused by charged particles known as reactive oxygen species. This oxidative stress is thought to add to the progression of several diseases, including type 2 diabetes.

Because antioxidants fight oxidative stress, they have become a popular food supplement. But Tiganis said the picture appears to be a bit more complicated.

“We think there is a delicate balance, and that too much of a good thing — surprise, surprise — might be bad,” he said.

Tiganis’ team studied the effects of oxidative stress in mice fed a high-fat diet for 12 weeks. One group of mice lacked an enzyme known as Gpxl, which helps counter oxidative stress.

They found mice that lacked the enzyme were less likely to develop insulin resistance — an early sign of diabetes — than normal mice. But when they treated the enzyme-deficient mice with an antioxidant, “they lost this advantage and become more ‘diabetic,” Tiganis said in an e-mail.

He said oxidative stress may be working not to damage the body but to inhibit enzymes that hurt the body’s ability to use insulin early on in the development of diabetes, and that antioxidants remove this protective mechanism.

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