Tag Archives: breast cancer risk

Pomegranate compounds may ease breast cancer risk

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Pomegranate compounds may ease breast cancer risk

Enzyme-blocking chemicals in pomegranates may reduce the risk of estrogen-fueled breast cancers, U.S. researchers said on Tuesday.

An acid found in pomegranates appears to block aromatase, an enzyme that converts androgen to estrogen, a hormone that plays a role in the development of breast cancer, the researchers wrote in the journal Cancer Prevention Research.

“We identified some of these chemicals in pomegranates that actually have properties that can suppress aromatase,” researcher Shiuan Chen, of the City of Hope cancer research and treatment center in Duarte, California, said in a telephone interview.

Many women who have had breast cancer take medicines called aromatase inhibitors — such as Pfizer’s Aromasin, Novartis’ Femara and AstraZeneca Plc’s Arimidex — to keep estrogen from feeding tumors.

Chen and colleagues studied whether compounds, or phytochemicals, in pomegranates can suppress aromatase and ultimately block cancer growth. They found that 10 natural compounds in the fruit may potentially prevent estrogen-related breast cancer.

Chen said the compounds would not be a replacement for aromatase inhibitors.

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Fitness ‘lowers breast cancer risk’

Fitness ‘lowers breast cancer risk’

Women who stay fit and physically active after the menopause can significantly reduce their risk of breast cancer, a study has shown.

But they have to work hard to get the benefit, spending more than seven hours a week taking “moderate-to-vigorous” exercise, say scientists.

“Light intensity” activities such as bowling, table tennis, fishing, slow walking and light gardening did not have the same effect. And no amount of exercise appeared to protect younger women during their fertile years.

Examples of “moderate-to-vigorous” activity given by the scientists included tennis, biking, swimming, weight-lifting, cheerleading, hiking, fast-walking, jogging and heavy housework and gardening.

Previous studies have linked physical activity and protection against breast cancer. But this was one of the first to look at the importance of different kinds of exercise at various stages of life.

Researchers asked more than 110,000 post-menopausal women to rate their activity levels at ages 15 to 18, 19 to 29, 35 to 39, and in the past 10 years.

Over a 6.6-year follow-up period, it was found that women in the last group who had done more than seven hours a week of moderate-to-vigorous exercise were 16% less likely to develop breast cancer than inactive women.

No link was seen between reduced breast cancer risk and physical activity at younger ages.

Light intensity exercise at any stage of life had no effect on the chances of developing breast cancer.

Breast cancer affects around 45,500 women each year in the UK and causes more than 12,400 deaths. An estimated one in nine women will suffer from the disease at some time in their life.

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For women on HRT, tenderness may be warning sign

July 11, 2012Uncategorizedand, archives of internal medicine, be, beating, bf1, blister, breast, breast cancer, breast cancer risk, breast exams, breast tenderness, california los angeles, calories, Choreography for Weight Health Story, colleagues, diet, dr carolyn, Drug, eating, estrogen plus progestin, Exercise, Flu, for, gallery, Gym, Health Health, health initiative, Health Latest, health video, history, hormone replacement therapy, HRT, in, laparoscopy, Malaysia Health, mammograms, may, medical, menopausal women, menopause, menopause symptoms, Nutrition, of, on, operation, organic, photo, physical, premarin, prempro, researchers, risk, risk for breast cancer, skin, spiritual, study, Surgery, symptoms, tips, to, training, university of california los angeles, video, video photo, video surgery, virus, warning sign, web Health, web Health picture, weightloss, WHI, whi study, women, women Picture, women Web, women for Weight gallery, women for Weight Health photo, women Gallery, women over Picture, women Photo Gallery, women Asia, women Health History, women Health Photo, women Video, women Health, women Health Information, women Health Latestazuan

For women on HRT, tenderness may be warning sign

Women whose breasts became tender after taking hormone replacement therapy had nearly twice the risk of developing breast cancer than women whose breasts did not become tender on the drugs, U.S. researchers said on Monday.

They said breast tenderness may be a way to identify women who have a higher risk of developing breast cancer while taking hormone replacement therapy to treat menopause.

“We report that an increase in breast tenderness, easily detected by physicians or patients, identifies a population at particular risk for breast cancer,” Dr. Carolyn Crandall of the University of California Los Angeles and colleagues reported in the Archives of Internal Medicine.

The team analyzed data on the more than 16,000 women who took estrogen-plus-progestin as part of the widely publicized Women’s Health Initiative or WHI study, which was halted in 2002 when researchers found healthy menopausal women who took the drugs were more likely to develop breast cancer.

Most of the women in the WHI studies took Premarin or Prempro made by Wyeth.

Doctors now recommend hormone replacement therapy for women suffering severe menopause symptoms, but caution that they should use the lowest dose possible for the shortest period of time.

Crandall and colleagues culled through the data to see if breast tenderness played a role in breast cancer risk. In the study, 8,506 took estrogen plus progestin and 8,102 got placebo pills.

The women had mammograms and breast exams at the start of the trial and every year after that. They reported whether they had breast tenderness at the beginning of the trial and a year later.

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