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Drinking shows little effect on stroke outcome

Drinking shows little effect on stroke outcome

While some research has suggested that moderate drinking may lower a person’s odds of suffering a stroke, a new study finds that it may have little long-term impact on stroke risk or stroke severity.

The findings, reported in the journal Stroke, come from a more than two-decade follow-up of nearly 22,000 U.S. male doctors. Researchers found that overall, there was no strong association between the men’s drinking habits and their odds of suffering a stroke.

Nor was there a clear connection between alcohol intake and the severity of disability following a stroke.

Some past studies, though not all, have suggested that light-to-moderate drinking may be protective against stroke — as it appears to be against heart disease. But the current study, which followed participants for an average of 22 years, was longer term than those earlier studies, the researchers point out.

In addition, a number of other studies have found that the protective effect of moderate drinking is generally weak and fades with longer-term follow-up, noted senior researcher Dr. Tobias Kurth, of the French national health institute INSERM, in Paris, and Brigham and Women’s Hospital in Boston.

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For women on HRT, tenderness may be warning sign

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For women on HRT, tenderness may be warning sign

Women whose breasts became tender after taking hormone replacement therapy had nearly twice the risk of developing breast cancer than women whose breasts did not become tender on the drugs, U.S. researchers said on Monday.

They said breast tenderness may be a way to identify women who have a higher risk of developing breast cancer while taking hormone replacement therapy to treat menopause.

“We report that an increase in breast tenderness, easily detected by physicians or patients, identifies a population at particular risk for breast cancer,” Dr. Carolyn Crandall of the University of California Los Angeles and colleagues reported in the Archives of Internal Medicine.

The team analyzed data on the more than 16,000 women who took estrogen-plus-progestin as part of the widely publicized Women’s Health Initiative or WHI study, which was halted in 2002 when researchers found healthy menopausal women who took the drugs were more likely to develop breast cancer.

Most of the women in the WHI studies took Premarin or Prempro made by Wyeth.

Doctors now recommend hormone replacement therapy for women suffering severe menopause symptoms, but caution that they should use the lowest dose possible for the shortest period of time.

Crandall and colleagues culled through the data to see if breast tenderness played a role in breast cancer risk. In the study, 8,506 took estrogen plus progestin and 8,102 got placebo pills.

The women had mammograms and breast exams at the start of the trial and every year after that. They reported whether they had breast tenderness at the beginning of the trial and a year later.

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Stressful childhood may mean earlier death

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Stressful childhood may mean earlier death

Having a stressful childhood may slash decades off a person’s life, researchers from the Centers for Disease Control and Prevention (CDC) report.

Among people who reported experiencing at least six of eight different bad childhood experiences-from frequent verbal abuse to living with a mentally ill person-average age at death was about 61, compared to 79 for people who didn’t have any of these experiences as children, the researchers found.

Dr. David W. Brown and Dr. Robert Anda of the CDC and colleagues from the CDC and Kaiser Permanente have been following 17,337 men and women who visited the health plan between 1995 and 1997 to investigate the relationship between bad childhood experiences and health.

So far, Anda noted in an interview, they have shown links between childhood stressors and heart disease, lung disease, liver disease and other conditions. “The strength of it really surprised me, how powerfully it’s related to health,” the researcher said.

In the current analysis, the researchers reviewed death records through 2006 to investigate whether these experiences might also relate to mortality. During that time, 1,539 study participants died.

Each person was asked whether they had any of eight different categories of such experiences, including verbal abuse, physical abuse, sexual abuse with physical contact, having a battered mother, having a substance-abusing person in the household, having a mentally ill person in the household, having a household member who was incarcerated, or having one’s parents separate or divorce.

Sixty-nine percent of the study participants who were younger than 65 reported at least one of the adverse childhood experiences, while 53 percent of people 65 and older did.

Those who reporting experiencing six or more were 1.5 times more likely to die during follow-up than those who reported none, the researchers found. They were 1.7 times as likely to die at age 75 or younger, and nearly 2.4 times as likely to die at or before age 65.

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