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Antioxidants may raise diabetes risk: study

July 4, 2012Uncategorizedan, and, antioxidants, Antioxidants Gallery, Antioxidants Photo Gallery, Antioxidants Asia, Antioxidants for Weight gallery, Antioxidants Health, Antioxidants Health History, Antioxidants Health Information, Antioxidants Health Latest, Antioxidants Health Photo, Antioxidants Picture, Antioxidants Video, Antioxidants Web, Antioxidantsfor Weight Health photo, Antioxidantsover Picture, Antioxidantsvideo, be, beating, bf1, blister, body, calories, Cancer, Choreography for Weight Health Story, diabetes, diabetes risk, diet, Drug, eating, Exercise, Flu, for, gallery, Gym, Health Health, Health Latest, health video, history, in, insulin, laparoscopy, Malaysia Health, may, medical, mice, Nutrition, of, operation, organic, photo, physical, picture, prevent, risk, risk study, skin, spiritual, stress, study, Surgery, symptoms, tips, to, training, type 2 diabetes, video, video photo, video surgery, virus, web Health, web Health picture, weightlossazuan

Antioxidants may raise diabetes risk: study

Instead of protecting against diabetes, antioxidants — compounds in foods and supplements that prevent cell damage — may actually increase the chances of getting diabetes, at least in the early stages, Australian researchers reported on Tuesday.

“In the case of early type 2 diabetes … our studies suggest that antioxidants would be bad for you,” Tony Tiganis of Monash University in Australia, whose study appears in the journal Cell Metabolism, said in a statement.

Antioxidants are protective proteins that can prevent cell damage caused by charged particles known as reactive oxygen species. This oxidative stress is thought to add to the progression of several diseases, including type 2 diabetes.

Because antioxidants fight oxidative stress, they have become a popular food supplement. But Tiganis said the picture appears to be a bit more complicated.

“We think there is a delicate balance, and that too much of a good thing — surprise, surprise — might be bad,” he said.

Tiganis’ team studied the effects of oxidative stress in mice fed a high-fat diet for 12 weeks. One group of mice lacked an enzyme known as Gpxl, which helps counter oxidative stress.

They found mice that lacked the enzyme were less likely to develop insulin resistance — an early sign of diabetes — than normal mice. But when they treated the enzyme-deficient mice with an antioxidant, “they lost this advantage and become more ‘diabetic,” Tiganis said in an e-mail.

He said oxidative stress may be working not to damage the body but to inhibit enzymes that hurt the body’s ability to use insulin early on in the development of diabetes, and that antioxidants remove this protective mechanism.

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Defibrillators may not save women, study finds

June 30, 2012Uncategorizedabnormal heart rhythms, and, archives of internal medicine, be, beating, bf1, blister, blood, california san francisco, calories, Cancer, chronic condition, clinical trials, dangerous heart, Defibrillators, Defibrillators Asia, Defibrillators Gallery, Defibrillators Health, Defibrillators Health History, Defibrillators Health Information, Defibrillators Health Latest, Defibrillators Photo Gallery, Defibrillators Picture, Defibrillators Video, Defibrillators Web, DefibrillatorsHealth latest, DefibrillatorsHealth Photo, Defibrillatorsover Picture, diet, Drug, eating, Exercise, Exercising for Weight Gallery, Exercising for Weight Health Story, Exercising for Weight Health Photo, Exercising Weight, Exercising Weight Health, Flu, for, gallery, Gym, Health Health, Health Latest, health video, Healthy Minnesota, Healthy Minnesota Asia, Healthy Minnesota Health Story, Healthy Minnesota Photo Gallery, heart, heart failure, heart institute, heart quivers, heart rhythm, heartbeat, history, hundreds of thousands, implantable defibrillators, in, laparoscopy, Malaysia Health, may, medical, nine times, not, Nutrition, of, operation, organic, organs, photo, physical, protect, providence hospital, skin, spiritual, study, substantial evidence, sudden cardiac death, Surgery, symptoms, tips, to, training, university of california san francisco, use implantable, video, video photo, video surgery, virus, web, web Health, web Health picture, weightloss, womenazuan

Defibrillators may not save women, study finds

Despite their widespread use, implantable defibrillators to protect against deadly heart rhythms do not prevent deaths in women with advanced heart failure, U.S. researchers said on Monday.

They said implantable defibrillators — which detect abnormal heart rhythms and offer a life-saving shock to restore a regular heartbeat — do not appear to protect men and women equally.

“There seems to be much less significant benefit” in women, said Dr. Christian Machado of Providence Hospital Heart Institute and Medical Center in Michigan, whose study appears in the Archives of Internal Medicine.

“Implantable cardioverter-defibrillators are being implanted in hundreds of thousands of women without substantial evidence of benefit,” Dr. Rita Redberg of the University of California, San Francisco, wrote in a commentary in the journal.

Nearly 22 million people worldwide suffer from heart failure, a chronic condition in which the heart struggles to pump blood. Heart failure affects about 5.3 million Americans, and nearly half are women.

People with heart failure are six to nine times more likely than most people to suffer sudden cardiac death, a dangerous heart rhythm in which the heart quivers but does not pump blood to the organs. Implantable defibrillators can detect this rhythm and deliver a shock to restore a normal heart beat.

Many clinical trials have found implantable defibrillators save lives and are cost-effective; but too often, the studies are overpopulated with men, Machado said.

He and colleagues searched published clinical trials data on implantable defibrillators from 1950 to 2008.

“Our trials are biased toward males. Seventy to 80 percent are made up of male subjects,” Machado said.

His team analyzed five trials with a total of 934 women with advanced heart failure. None showed defibrillators significantly decreased the rate of death from any cause compared with drug therapy alone.

Among the 3,810 men in the studies, however, there was a significant reduction in the rate of death among those who had a defibrillator.

Machado said many women with heart failure are routinely offered defibrillators to safeguard against sudden cardiac arrest, even though the device may not help them live longer.

He said it would not be ethical to do a randomized clinical trial to prove women do not benefit, but said ongoing studies should be sure to focus on the effects in both men and women.

“We need to do a better job in trials recruiting at least the same amount of women as we do men. We have failed to do that,” he said.

Implantable defibrillators, which cost between $20,000 to $30,000 to implant, represent a $6 billion global market for companies such as Medtronic Inc, Boston Scientific Corp and St. Jude Medical Inc.

Dr. Mark Carlson of medical device maker St. Jude Medical said in a statement that women enrolled in clinical studies evaluating heart failure have tended to be sicker than men in the same studies, and they have tended to be undertreated in general.

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Studies show one dose of H1N1 vaccine may be enough

June 27, 2012Uncategorizedasia studies, be, beating, bf1, blister, calories, Cancer, diet, dose, Drug, eating, enough, Exercise, Exercising for Weight Gallery, Exercising for Weight Health Story, Exercising for Weight Health Photo, Flu, flu drug, gallery, Gym, H1N1, Health Health, health history, health story, health studies, health video, health web, Healthy Minnesota, Healthy Minnesota Asia, Healthy Minnesota Health Story, Healthy Minnesota Photo Gallery, history, history studies, in, information studies, laparoscopy, Malaysia Health, may, medical, million, minnesota health, Nutrition, nutrition health, of, one, operation, organic, photo, photo studies, physical, show, skin, spiritual, Studies, Studies show, Studies show Asia, Studies show Gallery, Studies show Health, Studies show Health History, Studies show Health Information, Studies show Health Latest, Studies show Photo Gallery, Studies show Picture, Studies show Video, Studies show Web, Studies show Health Photo, Studies show over Picture, Surgery, swine flu, symptoms, tips, to, training, vaccine, video, video health, video photo, video studies, video surgery, virus, web Health, web Health picture, weight health, weightlossazuan

Studies show one dose of H1N1 vaccine may be enough

Two studies published on Thursday confirmed that a single dose of swine flu vaccine can protect people from the new pandemic H1N1 virus — welcome news to global health officials who had worried that people might need two doses.

Australian vaccine maker CSL Inc. released new data showing its vaccine got what would be considered a protective immune response with a singe dose, and Swiss drug maker Novartis presented a study confirming a report from last week showing its vaccine worked at an even lower dose when boosted with an immune system compound called an adjuvant.

Both studies, published in the New England Journal of Medicine, may lay to rest fears about the logistical nightmare of trying to vaccinate hundreds of millions of people globally with two doses of H1N1 vaccine — given a month apart — in addition to a single recommended dose of seasonal influenza vaccine.

Last week China’s Sinovac also reported its vaccine protected patients with a single dose.

The new H1N1 strain of flu, declared a pandemic in June, could eventually infect one third of the world’s population, or 2 billion people, according to the World Health Organization.

Because it is a new strain, infectious disease experts had said people would likely need two doses to get full immunity against the virus. They are rushing to put in place vaccine programs as the weather cools in the Northern Hemisphere and the traditional flu season starts.

About 20 pharmaceutical companies including Sanofi-Aventis, GlaxoSmithKline and AstraZeneca’s MedImmune unit are also racing to develop H1N1 vaccine as governments scramble to secure supplies.

The United States hopes to vaccinate 160 million Americans by the beginning of December.

NASAL SPRAY READY

Also on Thursday, MedImmune said its inhaled vaccine against the pandemic H1N1 virus could be ready to start shipping to the U.S. government by the end of September.

MedImmune’s Dr. Raburn Mallory said the company has submitted safety data for its nasal spray swine flu vaccine to the U.S. Food and Drug Administration.

“There are no red flags there. We think we can have 5 million doses ready to distribute at the end of September,” Mallory said in an interview. U.S. officials had not expected vaccination to begin until mid-October.

The company has 5 million doses in spray devices now, a company spokeswoman said, adding that a more conservative estimate would be that 3.5 million doses could be sent out by the end of September.

U.S. health officials said they started testing swine flu vaccines in pregnant women this week and were scheduled on Friday to report on results of some of the tests being done on various swine flu vaccines for the U.S. market.

The U.S. Food and Drug Administration is licensing H1N1 vaccines as if they are a simple reformulation of the seasonal flu vaccine. This does not require clinical tests, but the National Institutes of Health is running clinical tests anyway, to be sure it is safe and to find the best dose.

Governments in Europe have started to take delivery of H1N1 swine flu vaccines but are awaiting a license from European authorities before they can start mass vaccinations.

“The immune response to all these vaccines is a very high response, whatever type of vaccine it is, whether it is adjuvanted or non-adjuvanted,” Thomas Lonngren, executive director of the European Medicines Agency or EMEA, told a news briefing.

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