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Vitamins and Supplements

vitamins

Vitamins and Supplements

A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. A compound is called a vitamin when it cannot be synthesized in sufficient quantities by an organism, and must be obtained from the diet. Thus, the term is conditional both on the circumstances and the particular organism. For example, ascorbic acid functions as vitamin C for some animals but not others, and vitamins D and K are required in the human diet only in certain circumstances. The term vitamin does not include other essential nutrients such as dietary minerals, essential fatty acids, or essential amino acids, nor does it encompass the large number of other nutrients that promote health but are otherwise required less often.

Vitamins are classified by their biological and chemical activity, not their structure. Thus, each “vitamin” may refer to several vitamer compounds that all show the biological activity associated with a particular vitamin. Such a set of chemicals are grouped under an alphabetized vitamin “generic descriptor” title, such as “vitamin A,” which includes the compounds retinal, retinol, and many carotenoids. Vitamers are often inter-converted in the body.

History

The value of eating a certain food to maintain health was recognized long before vitamins were identified. The ancient Egyptians knew that feeding liver to a patient would help cure night blindness, an illness now known to be caused by a vitamin A deficiency.The advancement of ocean voyage during the Renaissance resulted in prolonged periods without access to fresh fruits and vegetables, and made illnesses from vitamin deficiency common among ships’ crews.

In 1749, the Scottish surgeon James Lind discovered that citrus foods helped prevent scurvy, a particularly deadly disease in which collagen is not properly formed, causing poor wound healing, bleeding of the gums, severe pain, and death. In 1753, Lind published his Treatise on the Scurvy, which recommended using lemons and limes to avoid scurvy, which was adopted by the British Royal Navy. This led to the nickname Limey for sailors of that organization. Lind’s discovery, however, was not widely accepted by individuals in the Royal Navy’s Arctic expeditions in the 19th century, where it was widely believed that scurvy could be prevented by practicing good hygiene, regular exercise, and by maintaining the morale of the crew while on board, rather than by a diet of fresh food. As a result, Arctic expeditions continued to be plagued by scurvy and other deficiency diseases. In the early 20th century, when Robert Falcon Scott made his two expeditions to the Antarctic, the prevailing medical theory was that scurvy was caused by “tainted” canned food.

Vitamins are essential for the normal growth and development of a multicellular organism. Using the genetic blueprint inherited from its parents, a fetus begins to develop, at the moment of conception, from the nutrients it absorbs. It requires certain vitamins and minerals to be present at certain times. These nutrients facilitate the chemical reactions that produce among other things, skin, bone, and muscle. If there is serious deficiency in one or more of these nutrients, a child may develop a deficiency disease. Even minor deficiencies may cause permanent damage.

In nutrition and diseases

For the most part, vitamins are obtained with food, but a few are obtained by other means. For example, microorganisms in the intestine—commonly known as “gut flora”—produce vitamin K and biotin, while one form of vitamin D is synthesized in the skin with the help of the natural ultraviolet wavelength of sunlight. Humans can produce some vitamins from precursors they consume. Examples include vitamin A, produced from beta carotene, and niacin, from the amino acid tryptophan.

Once growth and development are completed, vitamins remain essential nutrients for the healthy maintenance of the cells, tissues, and organs that make up a multicellular organism; they also enable a multicellular life form to efficiently use chemical energy provided by food it eats, and to help process the proteins, carbohydrates, and fats required for respiration.

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Drinking shows little effect on stroke outcome

Drinking shows little effect on stroke outcome

While some research has suggested that moderate drinking may lower a person’s odds of suffering a stroke, a new study finds that it may have little long-term impact on stroke risk or stroke severity.

The findings, reported in the journal Stroke, come from a more than two-decade follow-up of nearly 22,000 U.S. male doctors. Researchers found that overall, there was no strong association between the men’s drinking habits and their odds of suffering a stroke.

Nor was there a clear connection between alcohol intake and the severity of disability following a stroke.

Some past studies, though not all, have suggested that light-to-moderate drinking may be protective against stroke — as it appears to be against heart disease. But the current study, which followed participants for an average of 22 years, was longer term than those earlier studies, the researchers point out.

In addition, a number of other studies have found that the protective effect of moderate drinking is generally weak and fades with longer-term follow-up, noted senior researcher Dr. Tobias Kurth, of the French national health institute INSERM, in Paris, and Brigham and Women’s Hospital in Boston.

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U.S. pre-term babies die despite medical care: study

in.reuters.com

U.S. pre-term babies die despite medical care: study

Very early pre-term babies kept alive with ventilators, chest tubes and drugs to support the heart may live a little longer than they did 10 years ago, but are just as likely to die before ever going home, U.S. researchers reported on Monday.

Their study suggests the emotionally taxing and expensive care given these tiny newborns, delivered at 22 to 24 weeks gestation, does not in the end save their lives. Babies born at 22 weeks included in the study all died as infants, regardless of care.

“This is a very difficult ethical dilemma for everyone involved,” Pamela Donohue of Johns Hopkins Childrens Center in Baltimore, who led the study, said in a telephone interview.

Most pregnancies last about 40 weeks, and babies born earlier than 37 weeks of pregnancy are considered premature.

Donohue’s team studied 160 women who gave birth at 22-24 weeks during separate two-year periods — 1993-1995 and 2001-2003.

Those who gave birth during the current decade were more likely to receive higher-level care around the time of delivery, including sonograms, antibiotics and steroids to help with fetal lung development.

After birth, their children were more likely to be put on ventilators, drugs to boost heart and blood pressure rates and to have chest tubes inserted.

Infants born in 2001-2003 lived longer on average — seven days, compared to two days in the 1990s.

But mortality rates did not fall, and the researchers urged greater discussion and further study both on intervention and the degree of suffering imposed on children, their families and healthcare providers.

Very early pre-term babies kept alive with ventilators, chest tubes and drugs to support the heart may live a little longer than they did 10 years ago, but are just as likely to die before ever going home, U.S. researchers reported on Monday.

Their study suggests the emotionally taxing and expensive care given these tiny newborns, delivered at 22 to 24 weeks gestation, does not in the end save their lives. Babies born at 22 weeks included in the study all died as infants, regardless of care.

“This is a very difficult ethical dilemma for everyone involved,” Pamela Donohue of Johns Hopkins Childrens Center in Baltimore, who led the study, said in a telephone interview.

Most pregnancies last about 40 weeks, and babies born earlier than 37 weeks of pregnancy are considered premature.

Donohue’s team studied 160 women who gave birth at 22-24 weeks during separate two-year periods — 1993-1995 and 2001-2003.

Those who gave birth during the current decade were more likely to receive higher-level care around the time of delivery, including sonograms, antibiotics and steroids to help with fetal lung development.

After birth, their children were more likely to be put on ventilators, drugs to boost heart and blood pressure rates and to have chest tubes inserted.

Infants born in 2001-2003 lived longer on average — seven days, compared to two days in the 1990s.

But mortality rates did not fall, and the researchers urged greater discussion and further study both on intervention and the degree of suffering imposed on children, their families and healthcare providers.

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