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Long-term monkey tests back Oxford’s gene therapy

July 9, 2012Uncategorizedand, back, beating, bf1, blister, brain chemical, calories, chemical dopamine, Choreography for Weight Health Story, diet, dopamine levels, Drug, drugs, eating, Exercise, Flu, for, french researchers, gallery, gene therapy, Gym, Health Health, health history, Health Latest, health story, health video, history, in, involuntary movements, is, journal science, laparoscopy, Long term monkey, Long term monkey Picture, Long term monkey Web, Long term monkey for Weight gallery, Long term monkey for Weight Health photo, Long term monkey Gallery, Long term monkey Photo Gallery, Long term monkey Asia, Long term monkey Health History, Long term monkey Video, Long term monkey Health, Long term monkey Health Information, Long term monkey Health Latest, Long term monkey Health Photo, Long term monkey over Picture, macaque monkeys, Malaysia Health, medical, monkey health, motor deficits, neurotoxin, Nutrition, of, on, operation, oral drugs, organic, oxford biomedica, parkinsonism, photo, physical, picture, researchers, skin, spiritual, striatum, Surgery, symptoms, term tests, tips, to, training, translational medicine, video, video photo, video surgery, virus, web, web Health, web Health picture, weight health, weightlossazuan

Long-term monkey tests back Oxford’s gene therapy

Long-term tests on monkeys using Oxford BioMedica’s gene therapy ProSavin suggest it can treat Parkinson’s disease without causing the jerky, involuntary movements associated with current drugs, researchers said on Wednesday.

Parkinson’s is caused by lack of the brain chemical dopamine. Standard treatment involves oral drugs that briefly raise dopamine levels — but levels of the chemical still remain unstable, leading to a movement disorder called dyskinesias.

By contrast, tests on macaque monkeys found the gene therapy safely restored concentrations of dopamine in the brain, corrected motor deficits and prevented dyskinesias — with no severe adverse side effects.

French researchers observed the animals for up to three and a half years in the study, after first inducing Parkinsonian syndrome by giving a neurotoxin and then treating them with gene therapy injections.

“Gene therapy-mediated dopamine replacement may be able to correct Parkinsonism in patients without the complications of dyskinesias,” Bechir Jarraya and colleagues wrote in the journal Science Translational Medicine.

Oxford BioMedica is currently conducting Phase I/II clinical trials with ProSavin and in July announced encouraging initial results.

ProSavin, which is administered directly to the striatum in the brain, delivers three genes required to convert cells that normally do not produce dopamine into cells that do.

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Breast defence

July 9, 2012Uncategorizedabnormal growth, and, beating, bf1, birth control pills, blister, brca1 and brca2, brca1 and brca2 genes, breast, breast cancer, breast cancer causes, breast cancer increases, breast cancers, Breast defence, Breast defence Asia, Breast defence for Weight Health Story, Breast defence for Weight gallery, Breast defence for Weight Health photo, Breast defence Gallery, Breast defence Health, Breast defence Health History, Breast defence Health Information, Breast defence Health Latest, Breast defence Health Photo, Breast defence over Picture, Breast defence Video, Breast defence Web, Breast defence Photo Gallery, Breast defence Picture, breast tissue, calories, canadian women, Cancer, dense, diet, Drug, eating, estrogen production, Exercise, fat cells, Flu, for, gallery, genes, genetic mutations, genetic problems, genetic vulnerabilities, Gym, Health Health, health video, history, history of ovarian cancer, hormone replacement therapy, in, is, laparoscopy, lifestyle factors, Malaysia Health, medical, menopausal women, Nutrition, of, one, operation, organic, ovarian cancer, photo, physical, picture, post menopausal, radiation therapy, risk, skin, spiritual, Surgery, symptoms, The, tips, to, training, video, video photo, video surgery, virus, web, web Health, web Health picture, weightloss, woman, womenazuan

Breast defence

Some women have specific genetic problems but those breast cancers number less than 10% of all. One expert recently told me that breast cancer causes are “multifactorial” and that the combination of lifestyle factors and genetic vulnerabilities that accounts for the abnormal growth of cells is still being figured out.

That means that most of the 22,700 Canadian women (and 180 men) expected to be diagnosed this year won’t even know what caused their illness. Neither will the 5,400 women who die from it. Sometimes we forget just how many different factors may contribute to breast cancer’s development. Here’s what’s known:

ESTROGEN

The more estrogen a woman makes over time or takes through post-menopausal combined hormone replacement therapy, the higher her risk for getting breast cancer. The more years a woman menstruates, the longer breast tissue is estrogen-exposed. Birth control pills only slightly increase risk.

AGE

The chance of getting breast cancer increases as a woman ages. According to Dr. Love, from 20 to 30 the risk is one in 2,000; from 40 to 49 the risk is one in 68; from 60 to 69 the risk is one in 26. After the age of 70, a woman has a one-in-eight chance of getting breast cancer.

ALCOHOL

The risk of breast cancer jumped by 30% in women who drank more than three drinks daily.

FAMILY HISTORY

Having a mother, sister or daughter with breast cancer almost doubles a woman’s risk, particularly if the relative was diagnosed before age 50. A family history of ovarian cancer also increases the risk of developing breast cancer.

RADIATION

Radiation therapy for a previous cancer heightens the risk of breast cancer. The risk is highest if there was chest radiation during puberty.

OBESITY

Post-menopausal women who are obese are more at risk; fat cells play a role in estrogen production so being overweight adds to risky estrogen exposure.

GENETIC MUTATIONS

Those who have inherited changes in the BRCA1 and BRCA2 genes have a higher risk (some up to 90%) of getting the disease, and possibly at a younger age. Many other genes are also associated with breast cancer, including the HER-2/neu oncogene.

ENVIRONMENT

We’re exposed to vast amounts of hormone-mimicking and cell-interrupting chemicals in products we use and through environmental pollutants, some of which increases the risk of breast cancer.

BREAST DENSITY

Dense breast tissue, as shown on a mammogram, increases your risk. One study published in the Journal of the National Cancer Institute found that the relative risk of developing breast cancer in post-menopausal women with dense breasts was 400% higher than in women with fatty non-dense breasts.

BREAST DISEASE

Some diseases, including hyperplasia, can increase breast cancer risk by up to four-fold.

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Vaccines, hygiene could stop diarrhea deaths: U.N

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Vaccines, hygiene could stop diarrhea deaths: U.N

Diarrhea causes one in five child deaths across the world but getting important vaccines to Africa and Asia could help save many lives, two U.N. agencies said on Wednesday.

Some 1.5 million children die each year from diarrhea, — more than AIDS, malaria, and measles combined — yet only 39 percent of children with diarrhea in developing countries get the right treatment, the World Health Organization and the United Nations children’s fund UNICEF said in a report.

Vaccinations against rotavirus, the leading cause of severe gastroenteritis with vomiting and diarrhea in babies and children, as well as better sanitation and proper rehydration treatment would help solve the problem, they said.

Rotavirus causes around 40 percent of hospital admissions from diarrhea in children under five worldwide, according to the report, and vaccination against it has recently been recommended for all national immunization programs.

Only a few, mostly developed and richer nations include rotavirus vaccine in routine childhood immunization programs, but the WHO has been working to make two vaccines — Rotateq from Merck & Co and Rotarix from GlaxoSmithKline — more widely available in developing countries.

“Accelerating its introduction in Africa and Asia, where the rotavirus burden is greatest, needs to become an international priority,” said the report.

It also said two mainstays of diarrhea treatment — zinc supplements and low-osmolarity oral rehydration salts — are still hard to come by in many poorer countries.

“We know what works to reduce child deaths from diarrhea and what actions will make a lasting reduction in the burden of diarrhea,” Tessa Wardlaw of UNICEF and Elizabeth Mason of the WHO said in a commentary in The Lancet medical journal.

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