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For Heart Health, Focus on Risk Factors

For Heart Health, Focus on Risk Factors

Treating multiple factors that contribute to heart attack risk is better than simply focusing on lowering a patient’s cholesterol level, according to U.S. researchers.

“We’ve been worrying too much about people’s cholesterol level and not enough about their overall risk of heart disease,” Dr. Rodney A. Hayward, director of the Veterans Affairs Center for Health Services Research and Development, and a professor of internal medicine at the University of Michigan Medical School, said in a news release.

Levels of harmful LDL cholesterol should be less than 130 for most people and less than 70 for high-risk patients, according to the National Cholesterol Education Program.

In their study, Hayward and his colleagues analyzed data from Americans, aged 30 to 75, with no history of heart attack, who took part in clinical trials of cholesterol-lowering statin drugs. The researchers evaluated the benefit of five years of treatment tailored to a patient’s overall heart attack risk based on factors such as age, family history, diabetes, high blood pressure, smoking status and C-reactive protein level.

The results showed that the tailored treatment was more efficient (more benefit per person treated) and prevented substantially more heart attacks, strokes and cardiovascular deaths than simply reducing cholesterol to a certain target. The tailored treatment saved 500,000 more quality-adjusted life years than cholesterol-focused therapy, the researchers said.

“The bottom line message — knowing your overall heart attack risk is more important than knowing your cholesterol level. If your overall risk is elevated, you should probably be on a statin regardless of what your cholesterol is, and if your risk is very high, [you] should probably be on a high dose of statin,” Hayward said in the news release.

“However, if your LDL cholesterol is high, but your overall cardiac risk is low, taking a statin does not make sense for you. If your cholesterol is your only risk factor and you’re younger, you should work on diet and exercise,” he added.

The study was published online Jan. 18 in the Annals of Internal Medicine.
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Fast-acting impotency drug outpaces rivals: study

Fast-acting impotency drug outpaces rivals: study

Biotech firm Vivus unveiled a would-be player Monday in the 3.7-billion-dollar erectile dysfunction market: avanafil, effective in just 15 minutes, far faster than blockbuster rivals Viagra and Cialis.

“The magnitude of success in the first 15 minutes was surprising,” Leland Wilson, the company’s CEO, said in a statement.

Wilson put the spotlight on upbeat results for the class three investigational drug to treat male impotency, now in its last step before it can get a green light from the Food and Drug Administration (FDA).

“This new data further strengthens the profile and differentiation of avanafil from other currently available oral ED therapies,” Wilson said, referring to erectile dysfunction.

While “we knew from the pharmacokinetic profile that avanafil works very quickly, this data is exciting evidence of how fast avanafil really works,” he stressed.

“From our discussions with patients and physicians, we knew that rapid onset was an important attribute in the selection of an ED therapy,” he added.

Knowing avanafil acts in 15 minutes and lasts the length of a sexual encounter should be huge pluses for the drug in this highly lucrative market, said Dr Charles Bowden with Vivus.

The company is eyeing a market launch in early 2012.

Pfizer, which makes Viagra, says its drug acts within 30 minutes to an hour after it is taken. Cialis, made by Eli Lilly, starts working from 30 minutes to six hours after ingestion.

A third competitor, Levitra, acts starting between 25 and 60 minutes after it is taken.

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Does junk food at non-food stores add pounds?

Does junk food at non-food stores add pounds?

A new study shows that candy, soda and other junk foods are commonly sold at stores not traditionally associated with food — in a trend that researchers say may be contributing to the U.S. obesity problem.

The study, of more than 1,000 non-food retail stores across the U.S., found that 41 percent sold candy, soft drinks, chips and other sweet and salty snacks. The foods were most commonly placed at check-out counters, where they were “within arm’s reach” of impulsive buyers, the researchers report in the American Journal of Public Health.

Nearly all drug stores and gas stations in the study sold snack foods — as did a majority of general merchandise stores, hardware and garden stores and automobile repair shops.

Even some stores selling clothes, books or furniture offered customers a snack selection.

The problem, the researchers contend, is that this “ubiquity” of snack foods may tempt many people into buying calories that they otherwise would not.

And over time, those calories could add up to extra pounds, write Dr. Thomas A. Farley and colleagues at Tulane University School of Public Health in New Orleans.

A number of studies, the researchers note, have found that when people grab snacks throughout the day, they typically do not compensate by eating less at meals.

“This suggests that calories consumed through impulse purchases of snack foods will increase total daily (calorie) intake and thus contribute to weight gain,” Farley and his colleagues write in their report.

They estimate that if a person sees snack foods at retail stores twice per week, and ends up buying a typical product only 10 percent of the time, that would mean an extra 2,600 calories in a year. That, in turn, could translate to close to a pound of weight gain per year.

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