Tag Archives: study

Human Bodies Make Their Own Morphine

A laboratory morphine vial from the 1880s.

Our bodies produce a small but steady amount of natural morphine, a new study suggests.

Traces of the chemical are often found in mouse and human urine, leading scientists to wonder whether the drug is being made naturally or being delivered by something the subjects consumed.

The new research shows that mice produce the “incredible painkiller”—and that humans and other mammals possess the same chemical road map for making it, said study co-author Meinhart Zenk, who studies plant-based pharmaceuticals at the Donald Danforth Plant Science Center in St. Louis, Missouri.

In the study, researchers injected mice with an extra dose of a natural brain chemical called tetrahydropapaveroline (THP), which humans and mice are known to produce.

Using a tool called a mass spectrometer to analyze the mouse urine, the team was able to tell that THP underwent chemical changes in the body that created morphine, according to the study, published this week in the journal Proceedings of the National Academy of Sciences.

What’s more, the study found that mouse morphine is produced in nearly the same way as the morphine in poppies—the only morphine-making plants known to science.

Morphine a Defense Mechanism?

But “the big question is, What is it for?” Zenk said of the mammal-made morphine.

THP must undergo a complicated, 17-step process in the body to create morphine. Even so, the chemical has evolved twice—in poppies and in mammals—suggesting it’s somehow valuable for survival.

In the well-studied poppy plant, scientists suspect morphine acts as a defense against predators. For instance, a rabbit eating—and thus killing—a morphine-laced poppy may become sluggish, making itself easy prey for a passing hawk.

Likewise, Zenk noted, if an animal attacks a person, even background levels of morphine may block out enough pain to allow the person to escape. (Explore the human body.)

For now, however, this is “absolute speculation,” Zenk said. Next he plans to test the urine of people who have endured horrible pain—such as traffic-accident victims—to see if their bodies spiked morphine levels.

It’s also difficult to say whether the discovery will yield any new treatments, Zenk added. (Related: “Toxic Snail Venoms Yielding New Painkillers, Drugs.”)

But it’s possible that scientists could someday induce a person’s body to create a natural jolt of morphine that might prove less damaging than injecting the substance into the body. Morphine shots can carry many side effects, he said—especially constipation.

Drink warm water to ease effects of colon probes?

Drink warm water to ease effects of colon probes?

Drinking warm water seems to relax the bowel and improve the comfort of colonoscopy, as well as the “completeness” of the procedure, hint findings of a study from Korea.

Colonoscopy involves inserting a thin, flexible scope into the colon to look for cancer or polyps, which are growths that can become cancerous. With colonoscopy, the entire length of the colon can be inspected. It is considered the most sensitive way to screen for colon cancer.

However, “incomplete” colonoscopy examinations — when the full length of the colon can not be examined, for whatever reason — do occur and may lead to some small growths in the colon being missed, Dr. Jae J. Kim, at Sungkyunkwan University School of Medicine in Seoul noted in an email to Reuters Health.

In their study, Kim’s team found that they were able to completely examine more of the large intestine surface (98.4 percent on average) of patients who drank 2 liters (approximately 2 quarts) of warm water just prior to undergoing colonoscopy.

By contrast, colonoscopy reached lesser surface amounts (90.6 and 92.2 percent, respectively) in patients who drank 2 liters of cold water or no water, the researchers report in the American Journal of Gastroenterology.

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Newton’s Apple

Myth: Newton devised his universal law of gravity when an apple fell on his head from the tree under which he was sitting

It is always exciting to think of a great discovery happening in the blink of an eye due to a coincidental event – we consider that if it were not for the right person being in the right place at the right time, man would have lost an incredibly significant piece of knowledge. For this reason people have clung to the idea that Newton devised his universal law of gravity because of an apple hitting him on the head. But in fact the first mention of an apple in relation to Newton came 60 years after his death: “Whilst he was musing in a garden it came into his thought that the power of gravity (which brought an apple from the tree to the ground) was not limited to a certain distance from the earth but that this power must extend much further.” (John Conduitt)

Interesting Fact: Though he is better known for his love of science, the Bible was Sir Isaac Newton’s greatest passion. He devoted more time to the study of Scripture than to science, and he said, “I have a fundamental belief in the Bible as the Word of God, written by those who were inspired. I study the Bible daily.” He spent a great deal of time trying to discover hidden messages within the Bible.