Tag Archives: researchers

Most diabetics falling short on healthy eating

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Most diabetics falling short on healthy eating

Diabetes mellitus is a disease characterized by persistent hyperglycemia (high blood sugar levels), resulting either from inadequate secretion of the hormone insulin, an inadequate response of target cells to insulin, or a combination of these factors. Diabetes is a metabolic disease requiring medical diagnosis, treatment and lifestyle changes.

There are many causes and forms of diabetes known. The three most common patterns of diabetes have been recognized over the last thirty years as type 1, type 2 and gestational diabetes (or type 3)[1], although these three “types” of diabetes are more accurately considered patterns of pancreatic failure rather than single diseases. Each type can be produced by a variety of identifiable or yet-to-be-identified causes. There are some patients whose diabetes cannot be easily fit into one of these types, and some who display characteristics of more than one type at the same time.

Most Americans with diabetes are eating too much fat and sodium, and not enough fruits, vegetables, grains and low-fat dairy, a new study suggests.

The results, say researchers, indicate that many people with diabetes may need more education about the importance of nutrition in managing their condition.

Excess weight is one of the major risk factors for type 2 diabetes, a disorder in which the body can no longer properly use the blood sugar-regulating hormone insulin. Diet, exercise and weight loss are key to managing the disorder, and in some cases, weight loss can reverse the condition.

Yet in the new study, researchers found that of nearly 2,800 middle- aged and older U.S. adults with type 2 diabetes, nearly all were exceeding the daily recommended fat intake. When it came to artery-clogging saturated fat, 85 percent were consuming too much.

Similarly, 92 percent of study participants were consuming too much sodium, which can raise blood pressure and contribute to diabetics’ already elevated risks of heart disease and kidney disease. (See related Reuters Health story today.)

The researchers used a number of nutritional yardsticks, including the Food Guide Pyramid and recommendations by the Institute of Medicine. For example, experts recommend that adults get no more than 20 percent to 35 percent of their daily calories from fat, with less than 10 percent coming from saturated fat.

And if most study participants were getting too much of those nutrients, many were also not getting enough of certain healthy foods, the researchers report in the Journal of the American Dietetic Association.

Less than half were getting the minimum recommended servings of fruits, vegetables, dairy and grains each day.

“I thought we were going to find people who, because they have a chronic disease, were more educated about and more motivated than the average American to eat healthy, but that’s not the case,” lead researcher Dr. Mara C. Vitolins, of Wake-Forest University School of Medicine in Winston-Salem, North Carolina, said in a written statement.

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Cancer drug crosses key hurdle in brain: study

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Cancer drug crosses key hurdle in brain: study

An experimental drug appears to cross a protective barrier in the brain that screens out most chemicals, offering potentially better ways to treat brain tumors, U.S. researchers said on Sunday.

The drug, made by privately held Angiochem Inc of Montreal was safe and showed evidence it could shrink tumors in two separate early phase studies totaling more than 100 people with a brain cancer called glioblastoma.

It also worked among people whose cancers had spread or metastasized to the brain, the researchers reported at the annual meeting of the Society for Neuroscience in Chicago.

In both studies, tumors shrank in patients who got a higher dose of the drug, called ANG1005. The drug also showed signs of working in patients whose cancers resisted the chemotherapy drug taxane.

“It is highly encouraging to see that ANG1005 has shown the potential to be effective in metastatic brain cancers and against drug-resistant tumors,” Dr. Jan Drappatz of Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, who is studying the drug, said in a statement.

Drappatz said tumors shrank significantly in some patients and some neurological problems were reversed in several.

Studies of brain tumor samples showed concentrations of the drug in the tumors, proving it successfully crossed the blood-brain barrier and accumulated.

Made up of a network of blood vessels, the blood-brain barrier prevents 95 percent of all chemicals from leaving the bloodstream and entering the brain.

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New flu drug may resist mutations: researchers

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New flu drug may resist mutations: researchers

A new type of experimental flu drug that stops the virus from infecting cells appears to stop it from mutating into drug-resistant forms, researchers reported on Sunday.

Tests in mice and in lab dishes show that NexBio Inc.’s drug Fludase can stop the seasonal influenza virus from infecting cells and can fight strains of virus that have evolved resistance to Tamiflu, Roche AG’s popular influenza drug, the company said.

“Extensive, prolonged nonclinical influenza studies have not shown the development of any meaningful resistance,” the company said in a statement released at the Interscience Conference on Antimicrobial Agents and Chemotherapy in San Francisco.

Privately held NexBio Inc. said tests showed that Fludase, also known as DAS181, worked against the new H1N1 swine flu virus too.

Influenza viruses very quickly change to put up a strong defense against antiviral drugs. Last year the seasonal H1N1 virus developed strong resistance to Tamiflu. Two older flu drugs, amantadine and rimantadine, now have very little effect against influenza viruses.

Tamiflu and a similar drug, GlaxoSmithKline’s Relenza, affect a compound in the flu virus called neuraminadase — which gives flu viruses like H1N1 the “N” in their names.

Fludase affects the human cells that influenza infects, not the virus itself and that should make it less likely to cause the virus to develop resistance, company spokesman Dr. David Wurtman said.

It affects the sialic acid receptor — the molecular doorway that flu viruses use to attach to cells, he said.

“It makes it impossible to spread, so it can’t infect neighboring cells,” Wurtman said in a telephone interview.

Teams at the U.S. Centers for Disease Control and Prevention, University of Hong Kong and Saint Louis University in Missouri ran the experiments, the company said.

“Based on these encouraging data, we are moving forward with our ongoing clinical development of DAS181, and we will continue to work closely with FDA (the U.S. Food and Drug Administration), CDC and NIH (the National Institutes of Health) on this clinical program during the current pandemic,” Dr. Ronald Moss of NexBio, who presented the study, said in a statement.

Health experts predict that new drugs to fight flu will soon be needed, as the virus is mutation prone. Many are in development — furthest along is BioCryst’s peramivir, which would be made and sold in partnership with Japan’s Shionogi.

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