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Half of babies born in rich world will live to 100

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Half of babies born in rich world will live to 100

More than half of babies born in rich nations today will live to be 100 years old if current life expectancy trends continue, according to Danish researchers.

Increasing numbers of very old people could pose major challenges for health and social systems, but the research showed that may be mitigated by people not only living longer, but also staying healthier in their latter years.

“Very long lives are not the distant privilege of remote future generations — very long lives are the probable destiny of most people alive now in developed countries,” Kaare Christensen of the Danish Aging Research Center wrote on Friday in a study in the Lancet medical journal.

The study used Germany as a case study and showed that by 2050, its population will be substantially older and smaller than now — a situation it said was now typical of rich nations.

This means smaller workforces in rich nations will have to shoulder an ever-greater burden of ballooning pension and healthcare requirements of the old.

Many governments in developed nations are already making moves toward raising the typical age of retirement to try to cope with aging populations.

The researchers said this was an important strategy, and added that if part-time work was considered for more of the workforce, that could have yet more benefits.

“If people in their 60s and early 70s worked much more than they do nowadays, then most people could work fewer hours per week,” they wrote. “Preliminary evidence suggests that shortened working weeks over extended working lives might further contribute to increases in life expectancy and health.”

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Defibrillators may not save women, study finds

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Defibrillators may not save women, study finds

Despite their widespread use, implantable defibrillators to protect against deadly heart rhythms do not prevent deaths in women with advanced heart failure, U.S. researchers said on Monday.

They said implantable defibrillators — which detect abnormal heart rhythms and offer a life-saving shock to restore a regular heartbeat — do not appear to protect men and women equally.

“There seems to be much less significant benefit” in women, said Dr. Christian Machado of Providence Hospital Heart Institute and Medical Center in Michigan, whose study appears in the Archives of Internal Medicine.

“Implantable cardioverter-defibrillators are being implanted in hundreds of thousands of women without substantial evidence of benefit,” Dr. Rita Redberg of the University of California, San Francisco, wrote in a commentary in the journal.

Nearly 22 million people worldwide suffer from heart failure, a chronic condition in which the heart struggles to pump blood. Heart failure affects about 5.3 million Americans, and nearly half are women.

People with heart failure are six to nine times more likely than most people to suffer sudden cardiac death, a dangerous heart rhythm in which the heart quivers but does not pump blood to the organs. Implantable defibrillators can detect this rhythm and deliver a shock to restore a normal heart beat.

Many clinical trials have found implantable defibrillators save lives and are cost-effective; but too often, the studies are overpopulated with men, Machado said.

He and colleagues searched published clinical trials data on implantable defibrillators from 1950 to 2008.

“Our trials are biased toward males. Seventy to 80 percent are made up of male subjects,” Machado said.

His team analyzed five trials with a total of 934 women with advanced heart failure. None showed defibrillators significantly decreased the rate of death from any cause compared with drug therapy alone.

Among the 3,810 men in the studies, however, there was a significant reduction in the rate of death among those who had a defibrillator.

Machado said many women with heart failure are routinely offered defibrillators to safeguard against sudden cardiac arrest, even though the device may not help them live longer.

He said it would not be ethical to do a randomized clinical trial to prove women do not benefit, but said ongoing studies should be sure to focus on the effects in both men and women.

“We need to do a better job in trials recruiting at least the same amount of women as we do men. We have failed to do that,” he said.

Implantable defibrillators, which cost between $20,000 to $30,000 to implant, represent a $6 billion global market for companies such as Medtronic Inc, Boston Scientific Corp and St. Jude Medical Inc.

Dr. Mark Carlson of medical device maker St. Jude Medical said in a statement that women enrolled in clinical studies evaluating heart failure have tended to be sicker than men in the same studies, and they have tended to be undertreated in general.

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Studies show one dose of H1N1 vaccine may be enough

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Studies show one dose of H1N1 vaccine may be enough

Two studies published on Thursday confirmed that a single dose of swine flu vaccine can protect people from the new pandemic H1N1 virus — welcome news to global health officials who had worried that people might need two doses.

Australian vaccine maker CSL Inc. released new data showing its vaccine got what would be considered a protective immune response with a singe dose, and Swiss drug maker Novartis presented a study confirming a report from last week showing its vaccine worked at an even lower dose when boosted with an immune system compound called an adjuvant.

Both studies, published in the New England Journal of Medicine, may lay to rest fears about the logistical nightmare of trying to vaccinate hundreds of millions of people globally with two doses of H1N1 vaccine — given a month apart — in addition to a single recommended dose of seasonal influenza vaccine.

Last week China’s Sinovac also reported its vaccine protected patients with a single dose.

The new H1N1 strain of flu, declared a pandemic in June, could eventually infect one third of the world’s population, or 2 billion people, according to the World Health Organization.

Because it is a new strain, infectious disease experts had said people would likely need two doses to get full immunity against the virus. They are rushing to put in place vaccine programs as the weather cools in the Northern Hemisphere and the traditional flu season starts.

About 20 pharmaceutical companies including Sanofi-Aventis, GlaxoSmithKline and AstraZeneca’s MedImmune unit are also racing to develop H1N1 vaccine as governments scramble to secure supplies.

The United States hopes to vaccinate 160 million Americans by the beginning of December.

NASAL SPRAY READY

Also on Thursday, MedImmune said its inhaled vaccine against the pandemic H1N1 virus could be ready to start shipping to the U.S. government by the end of September.

MedImmune’s Dr. Raburn Mallory said the company has submitted safety data for its nasal spray swine flu vaccine to the U.S. Food and Drug Administration.

“There are no red flags there. We think we can have 5 million doses ready to distribute at the end of September,” Mallory said in an interview. U.S. officials had not expected vaccination to begin until mid-October.

The company has 5 million doses in spray devices now, a company spokeswoman said, adding that a more conservative estimate would be that 3.5 million doses could be sent out by the end of September.

U.S. health officials said they started testing swine flu vaccines in pregnant women this week and were scheduled on Friday to report on results of some of the tests being done on various swine flu vaccines for the U.S. market.

The U.S. Food and Drug Administration is licensing H1N1 vaccines as if they are a simple reformulation of the seasonal flu vaccine. This does not require clinical tests, but the National Institutes of Health is running clinical tests anyway, to be sure it is safe and to find the best dose.

Governments in Europe have started to take delivery of H1N1 swine flu vaccines but are awaiting a license from European authorities before they can start mass vaccinations.

“The immune response to all these vaccines is a very high response, whatever type of vaccine it is, whether it is adjuvanted or non-adjuvanted,” Thomas Lonngren, executive director of the European Medicines Agency or EMEA, told a news briefing.

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