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Combo pill an option for diabetes-related nerve pain

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Combo pill an option for diabetes-related nerve pain

A single pill containing the pain relievers tramadol and acetaminophen is as effective as the drug gabapentin for treating diabetes-related nerve pain, according to study findings presented Tuesday at the 20th World Diabetes Congress in Montreal.

Gabapentin is an anti-seizure drug frequently prescribed for epilepsy. The drug is also used to treat persistent neurological pain.

In general, gabapentin is regarded as a first-line therapy for “diabetic neuropathy” — a painful condition that causes a range of symptoms from a tingling sensation or numbness in the toes and fingers to paralysis, lead researcher Dr. Bong Yun Cha, from the Catholic University of Korea, Seoul, told Reuters Health.

In the current study, Cha and colleagues compared gabapentin with the tramadol/acetaminophen (TA) combination pill in adults with painful diabetic neuropathy in the lower extremities. Sixty-six study subjects received TA and 73 received gabapentin.

The study was sponsored by JANSSEN KOREA, which markets the combination pill as Ultracet in the US.

Cha and colleagues report that the two groups experienced similar improvements in pain and related parameters over the 6-week study period.

Moreover, the rate of treatment-associated side events in the TA group was not significantly different from that in the gabapentin group: 50.6 percent vs. 36.9 percent.

The current findings, said Cha, support TA as a suitable alternative to gabapentin as a first-line therapy for painful diabetic neuropathy.

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Healthier U.S. school meals boost costs: study

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Healthier U.S. school meals boost costs: study

Improving nutritional value of U.S. school food programs by increasing servings of fruits, vegetables and whole grains could increase the cost of breakfast by as much as 25 percent and lunch by 9 percent, according to a report released on Tuesday.

A report from the Institute of Medicine, an arm of the National Academies, proposed updating school meal programs to meet nutritional needs and foster better eating habits, but recognized healthier, fresher ingredients would boost costs, especially at breakfast where fruit servings would increase.

“It will cost a little more,” Virginia Stallings, a professor at The Children’s Hospital of Philadelphia and chair of the group that conducted the study, said in an interview.

“But this will be a very wise investment in children’s health,” she added.

Most school food providers would need more government money to help pay for food, training and equipment, the report said.

The Institute of Medicine conducted the review of the country’s school breakfast and lunch programs at the request of the U.S. Agriculture Department, which oversees them. School meal programs provide 40 million meals daily and more than half of students’ food and nutrient intake during the school day.

Child nutrition programs, which cost about $21 billion a year, are due for reauthorization this year but Congress is not expected to approve an overhaul for some time.

Officials at the USDA are updating the nutrition and meal requirements used for school breakfast and lunch programs, and looked for recommendations from the Institute of Medicine. The framework, last updated in 1995, sets food and nutrient standards that must be met by school programs to qualify for cash reimbursements and food from the government.

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Antioxidants may raise diabetes risk: study

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Antioxidants may raise diabetes risk: study

Instead of protecting against diabetes, antioxidants — compounds in foods and supplements that prevent cell damage — may actually increase the chances of getting diabetes, at least in the early stages, Australian researchers reported on Tuesday.

“In the case of early type 2 diabetes … our studies suggest that antioxidants would be bad for you,” Tony Tiganis of Monash University in Australia, whose study appears in the journal Cell Metabolism, said in a statement.

Antioxidants are protective proteins that can prevent cell damage caused by charged particles known as reactive oxygen species. This oxidative stress is thought to add to the progression of several diseases, including type 2 diabetes.

Because antioxidants fight oxidative stress, they have become a popular food supplement. But Tiganis said the picture appears to be a bit more complicated.

“We think there is a delicate balance, and that too much of a good thing — surprise, surprise — might be bad,” he said.

Tiganis’ team studied the effects of oxidative stress in mice fed a high-fat diet for 12 weeks. One group of mice lacked an enzyme known as Gpxl, which helps counter oxidative stress.

They found mice that lacked the enzyme were less likely to develop insulin resistance — an early sign of diabetes — than normal mice. But when they treated the enzyme-deficient mice with an antioxidant, “they lost this advantage and become more ‘diabetic,” Tiganis said in an e-mail.

He said oxidative stress may be working not to damage the body but to inhibit enzymes that hurt the body’s ability to use insulin early on in the development of diabetes, and that antioxidants remove this protective mechanism.

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