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Fast-acting impotency drug outpaces rivals: study

Fast-acting impotency drug outpaces rivals: study

Biotech firm Vivus unveiled a would-be player Monday in the 3.7-billion-dollar erectile dysfunction market: avanafil, effective in just 15 minutes, far faster than blockbuster rivals Viagra and Cialis.

“The magnitude of success in the first 15 minutes was surprising,” Leland Wilson, the company’s CEO, said in a statement.

Wilson put the spotlight on upbeat results for the class three investigational drug to treat male impotency, now in its last step before it can get a green light from the Food and Drug Administration (FDA).

“This new data further strengthens the profile and differentiation of avanafil from other currently available oral ED therapies,” Wilson said, referring to erectile dysfunction.

While “we knew from the pharmacokinetic profile that avanafil works very quickly, this data is exciting evidence of how fast avanafil really works,” he stressed.

“From our discussions with patients and physicians, we knew that rapid onset was an important attribute in the selection of an ED therapy,” he added.

Knowing avanafil acts in 15 minutes and lasts the length of a sexual encounter should be huge pluses for the drug in this highly lucrative market, said Dr Charles Bowden with Vivus.

The company is eyeing a market launch in early 2012.

Pfizer, which makes Viagra, says its drug acts within 30 minutes to an hour after it is taken. Cialis, made by Eli Lilly, starts working from 30 minutes to six hours after ingestion.

A third competitor, Levitra, acts starting between 25 and 60 minutes after it is taken.

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If you smoke, watch out for low back pain

If you smoke, watch out for low back pain

If you needed another reason to cut the cigarette habit: Smokers, especially younger smokers, are more likely to report low back pain than people who have never smoked, according to a new analysis.

After examining existing research, Finnish researchers concluded smoking is “modestly” associated with the risk of low back pain and the effects may be “at least partly reversible.” Their findings are published in the January issue of the American Journal of Medicine.

Dr. Rahman Shiri of the Finnish Institute of Occupational Health and colleagues wanted to know if smoking increases the risk of low back pain, a problem that affects an estimated 8 in 10 adults during some point in their lives.

Previous analysis of the existing research came to different conclusions, with one study suggesting an association between smoking and low back pain and the other reporting “unclear findings.”

The Finnish researchers identified and reviewed 81 studies from around the world involving smokers, former smokers, or never-smokers and low back pain conducted between 1966 and 2009. Of those, 40 studies involving more than 300,000 adults and adolescents met the standards for the analysis.

The Finnish team subjected the data of the individual studies to further statistical analysis to tease out the strength of relationships even as the studies reported various outcomes.

They determined that even though the data did not prove smoking leads to low back pain, the analysis of previous the literature suggested a “fairly modest” association between smoking and low back pain.

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Nose treatment cuts hospital-acquired infections

Nose treatment cuts hospital-acquired infections

If you’re checking into the hospital for surgery, doctors may soon be swabbing your nose in an effort to prevent an infection from appearing after your operation.

Researchers in the Netherlands said on Wednesday they were able to cut the risk of a common bacterium by nearly 60 percent by first looking for signs of it in the nose and then treating it with an antibiotic nasal gel and full body wash.

The treatment combination also shaved two days off a typical 14-day stay in the hospital.

Hospital-acquired infections are a major problem in medicine, so doctors are always looking for the best way to reduce the risk.

About 27 million surgeries are done just in the United States each year, and in as many as half a million cases, infections occur at the site of surgery.

Up to 30 percent of those infections are caused by strains of the bacterium Staphylococcus aureus, which otherwise benignly resides in the nose and on the skin.

The new study, published in the New England Journal of Medicine, used a rapid test to identify which patients, most of whom were scheduled to undergo surgery, had the bacteria in at least one nostril.

The 504 patients treated with the antibiotic nose gel mupirocin, also known as Bactroban, and washed with chlorhexidine, a common ingredient in mouthwash, developed an S. aureus infection 3.4 percent of the time. The rate for 413 volunteers given placebo treatment was 7.7 percent.

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