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Disease

Skin cancer can be inherited: studies

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Skin cancer can be inherited: studies

One found that having an identical twin with melanoma increased a person’s own risk of developing the disease much more than having a fraternal twin with this type of skin cancer. The other found that having a sibling or parent with one of several different types of non-melanoma skin cancer increased risk as well.

Several studies have suggested melanoma and other skin cancers run in families, but it can be difficult to tease out the difference between the influence of genes and environment. In the Australian study, Dr. Sri N. Shekar of the University of Queensland in Brisbane and his colleagues attempted to do so by looking at twin pairs in which at least one sibling had been diagnosed with melanoma.

They searched through thousands of cases of melanoma reported in Queensland and New South Wales and found 125 twin pairs. In four of the 27 identical twin pairs, both had melanoma, while three of the 98 fraternal twin pairs had both been diagnosed with the deadly skin cancer.

Based on these numbers, having an identical twin with melanoma increased a person’s own risk of the disease nearly 10-fold, while melanoma associated with having a non-identical twin with the disease was roughly doubled.

This suggests, the researchers say, that some of the increased melanoma risk can be attributed to genes, in particular interactions between genes. They estimate that genes account for about half of the differences in risk between two people.

In the second study, Dr. Shehnaz K. Hussain of the University of California Los Angeles and colleagues looked at the Swedish Family-Cancer Database to gauge the risk for several types of skin cancer among siblings and children of people diagnosed with these diseases.

They found that people with a sibling or parent diagnosed with some types of skin cancer were more likely to develop skin cancers of various types, not just the ones their relatives had. When tumors occurred at parts of the body more likely to have been exposed to the sun (such as the face, compared to the torso), the familial risk was stronger.

Based on the findings, Hussain and colleagues conclude, a person’s family history can be used to gauge their own skin cancer risk, and genetic studies could be a useful way to identify potential targets for treating or preventing the disease.

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Cancer

A young woman exhales cigarette smoke in Shanghai, China. The People’s Republic of China is both the world’s largest producer and largest consumer of tobacco, which has led to an impending cancer epidemic in the most populous country on Earth.

Cancer is a disease that begins as a renegade human cell over which the body has lost control. In order for the body and its organs to function properly, cell growth needs to be strictly regulated. Cancer cells, however, continue to divide and multiply at their own speed, forming abnormal lumps, or tumors. An estimated 6.7 million people currently die from cancer every year.

Not all cancers are natural-born killers. Some tumors are referred to as benign because they don’t spread elsewhere in the body. But cells of malignant tumors do invade other tissues and will continue to spread if left untreated, often leading to secondary cancers.

Cancers can start in almost any body cell, due to damage or defects in genes involved in cell division. Mutations build up over time, which is why people tend to develop cancer later in life. What actually triggers these cell changes remains unclear, but diet, lifestyle, viral infections, exposure to radiation or harmful chemicals, and inherited genes are among factors thought to affect a person’s risk of cancer.

Lung cancer is the world’s most killing cancer. It claims about 1.2 million victims a year. Most of those victims are smokers, who inhale cancer-causing substances called carcinogens with every puff. Experts say around 90 percent of lung cancer cases are due to tobacco smoking.

Breast cancer now accounts for almost one in four cancers diagnosed in women. Studies suggest the genes you inherit can affect the chances of developing the illness. A woman with an affected mother or sister is about twice as likely to develop breast cancer as a woman with no family history of the disease. Lifestyle may also have an influence, particularly in Western countries where many women are having children later. Women who first give birth after the age of 30 are thought to have a three times greater risk of breast cancer than those who became mothers in their teens.

Geographical Distinctions

There are also stark geographic differences, with incidence rates varying by as much as thirtyfold between regions. In much of Asia and South and Central America, for example, cervix cancer is the most deadly in females. However, in North America and Europe another kind of gynecological cancer, ovarian cancer, is a more serious threat.

Among males, southern and eastern Africa record the second and third highest rates of oesophageal, or gullet, cancer after China, but western and central regions of Africa have the lowest incidence in the world. Differences in diet may explain this.

Nevertheless, the reasons why many cancers develop remain elusive. Brain cancer, leukemia (blood cancer), and lymphoma (cancer of the lymph glands) are among types that still mystify scientists.

Treatments

Yet ever more people are surviving diagnosis thanks to earlier detection, better screening, and improved treatments. The three main treatment options are surgery, radiotherapy and chemotherapy. Radiotherapy, also called radiation therapy, involves blasting tumors with high-energy x-rays to shrink them and destroy cancerous cells. Chemotherapy employs cancer-killing drugs.

Even so, future cancer cases are predicted to climb, since the world’s population is aging. The proportion of people over age 60 is expected to more than double by 2050, rising from 10 percent to 22 percent. This will add an estimated 4.7 million to the cancer death toll by 2030.


Breast cancer patients have low vitamin D levels

Breast check

Breast cancer patients have low vitamin D levels

In a study of 166 women undergoing treatment for breast cancer, nearly 70 percent had low levels of vitamin D in their blood, according to the study presented at the American Society of Clinical Oncology’s Breast Cancer Symposium in San Francisco.

The analysis showed women with late-stage disease and non-Caucasian women had even lower levels.

“Vitamin D is essential to maintaining bone health, and women with breast cancer have accelerated bone loss due to the nature of hormone therapy and chemotherapy. It’s important for women and their doctors to work together to boost their vitamin D intake,” said Luke Peppone, Ph.D., research assistant professor of Radiation Oncology, at Rochester’s James P. Wilmot Cancer Center.

Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D — 50,000 international units or more — improved the levels, according to Peppone’s study.

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