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Ageing heart can be prevented, say scientists

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Ageing heart can be prevented, say scientists

Scientists in Japan said they have uncovered evidence that shows it may be possible to delay or prevent heart failure in humans.

In a paper published in the journal Circulation, Tetsuo Shioi, lead researcher and assistant professor of medicine at Kyoto University Graduate School of Medicine in Kyoto, and his team described how they managed to suppress a variety of the P13K gene in a group of elderly mice.

The gene regulates the lifespan of cells and plays a role in the aging of tissues. In previous studies, suppression of this gene extended the lifespan of the roundworm and kept the hearts of old fruit flies healthy.

Compared with another group of mice in which the gene was left intact, mice with the suppressed gene had improved cardiac function, less fibrosis (which makes the heart inflexible) and fewer biological markers of aging.

“This study showed that aging of the heart can be prevented by modifying the function of insulin and paves the way to preventing age-associated susceptibility to heart failure,” Shioi said.

Old age is a major risk factor for heart failure, a condition when the heart is unable to pump enough blood around to supply the oxygen the body needs, the World Health Organization says.

According to the American Heart Association, 5.7 million Americans have heart failure, and nearly 10 out of every 1,000 people over age 65 suffer heart failure every year.

Mariell Jessup, professor of medicine at the University of Pennsylvania School of Medicine in Philadelphia, said older people experience a slow but gradual loss of heart cells and a host of other cellular abnormalities which make the remaining cells contract less efficiently.

“This early work in a mouse model, clarifying the role of PI3K in cardiac aging, could ultimately allow scientists to understand if human hearts are similarly influenced,” he said.

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Stressful childhood may mean earlier death

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Stressful childhood may mean earlier death

Having a stressful childhood may slash decades off a person’s life, researchers from the Centers for Disease Control and Prevention (CDC) report.

Among people who reported experiencing at least six of eight different bad childhood experiences-from frequent verbal abuse to living with a mentally ill person-average age at death was about 61, compared to 79 for people who didn’t have any of these experiences as children, the researchers found.

Dr. David W. Brown and Dr. Robert Anda of the CDC and colleagues from the CDC and Kaiser Permanente have been following 17,337 men and women who visited the health plan between 1995 and 1997 to investigate the relationship between bad childhood experiences and health.

So far, Anda noted in an interview, they have shown links between childhood stressors and heart disease, lung disease, liver disease and other conditions. “The strength of it really surprised me, how powerfully it’s related to health,” the researcher said.

In the current analysis, the researchers reviewed death records through 2006 to investigate whether these experiences might also relate to mortality. During that time, 1,539 study participants died.

Each person was asked whether they had any of eight different categories of such experiences, including verbal abuse, physical abuse, sexual abuse with physical contact, having a battered mother, having a substance-abusing person in the household, having a mentally ill person in the household, having a household member who was incarcerated, or having one’s parents separate or divorce.

Sixty-nine percent of the study participants who were younger than 65 reported at least one of the adverse childhood experiences, while 53 percent of people 65 and older did.

Those who reporting experiencing six or more were 1.5 times more likely to die during follow-up than those who reported none, the researchers found. They were 1.7 times as likely to die at age 75 or younger, and nearly 2.4 times as likely to die at or before age 65.

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Canada bans fruit-flavored cigarettes

Canada bans fruit-flavored cigarettes

Canada has banned the manufacture, importation and sale of most flavored cigarettes and small cigars, which have been slammed as little more than an enticement to get children to start smoking.

The law, which came into effect on Thursday, was backed by both government and opposition lawmakers. It also bans tobacco advertising in newspapers and magazines, closing a loophole that had allowed ads in publications that claimed they were read only by adults.

Anti-smoking groups said fruit-flavored cigarettes were marketed like candy to lure young smokers, but the industry complained the law was too broad and would unfairly restrict importation of U.S.-grown burley tobacco.

Lawmakers in U.S. tobacco-growing states have complained the law will cost U.S. jobs, and a U.S. Senator has been blocking the appointment of a White House trade official in a bid to make the Obama administration put pressure on Canada.

Anti-smoking groups say the jobs complaint is unfounded since Canada did not import any U.S.-grown burley tobacco in 2007 and 2008, and “American-style” cigarettes make up less than 1 percent of the Canadian market.

“The trade argument was invented out of thin air,” said Rob Cunningham of the Canadian Cancer Society.

The Canadian ban is more sweeping than one imposed last month by the U.S. Food and Drug Administration because it also includes small cigars. Nether ban includes menthol-flavored cigarettes.

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