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Eggs for making H1N1 vaccine meet world standards

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Eggs for making H1N1 vaccine meet world standards

An egg is a round or oval body laid by the female of any number of different species, consisting of an ovum surrounded by layers of membranes and an outer casing, which acts to nourish and protect a developing embryo and its nutrient reserves. Most edible eggs, including bird eggs and turtle eggs, consist of a protective, oval eggshell, the albumen (egg white), the vitellus (egg yolk), and various thin membranes. Every part is edible, although the eggshell is generally discarded. Eggs are considered a good source of protein and choline. Because of this, the egg falls in the Meats category under the Food Guide Pyramid.

Roe and caviar are edible eggs produced by fish.

The eggs provided by two local companies to be used in the manufacture of H1N1 vaccine by Adimmune Corp. meet both world and local standards, the Central Epidemic Command Center under the Cabinet-level Department of Health (DOH) said Wednesday.”The eggs being used by Adimmune to produce HINI vaccine scrupulously meet the international standards set forth by the World Health Organization (WHO) and by Good Manufacturing Practice (GMP) criteria imposed by the DOH for high-quality food, ” the center said in response to a report by Next Magazine that questioned the safety of the eggs used by Taiwan’s sole human vaccine manufacturer.

Chen Hui-fang, director-general of the Bureau of Pharmaceutical Affairs under the DOH, said that in line with WHO guidelines, embryo eggs used to make vaccine must come from healthy chickens of adequate maturity and that such eggs supplied by two local providers fully meet the WHO regulations.

Eggs produced by chickens in the two enclosed farms are being raised in a fully automated and safe environment with round-the-clock monitoring, Chen said.

According to Chen, the bureau dispatched officials to inspect the production operations for the embryo eggs late last month, and no bacteria or residue from antibiotics or hormones were detected.

A day earlier, an Adimmune executive said the company’s vaccine production had entered the “filling stage,” which means that the dose of the vaccine has largely been established.

The executive added that the company is expected to launch human clinical trials in two weeks, to be conducted at the National Taiwan University (NTU) Hospital, the Tri-Service General Hospital and the Taipei Medical University-Wan Fang Hospital.

The company is recruiting 250 adults and 150 children to take part in the trials, he noted.

Immunizations are expected to begin in late October, with healthcare workers, pregnant women and children between 6 months and 6 years selected as priority recipients.

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Vaccines could halve sickle-cell deaths in Africa

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Vaccines could halve sickle-cell deaths in Africa

Vaccination against bacterial infections using vaccines readily available in developed countries could save the lives of thousands of children with sickle-cell anemia in Africa, researchers said on Thursday.

Tom Williams, an expert in tropical diseases from the Kenya Medical Research Institute (KEMRI), said 90 percent of children born with sickle-cell anemia in Africa die before they are diagnosed and can get treatment, and half of those lives could be saved if sufferers were protected from bacterial infections.

“The problem here in Africa is that there is hardly anyone doing any screening,” Williams said. “So, as a result, most of the children in Africa who are born with sickle-cell anemia are dead before they are even diagnosed.”

Experts estimate that sickle-cell anemia kills more children in Africa than HIV, Williams said, but while HIV commands vast attention from the international community sickle-cell anemia is “virtually invisible.”

In a study conducted in rural Kenya and published in the Lancet medical journal, Williams and colleagues at the KEMRI/Wellcome Trust program in Kilifi screened almost 40,000 admissions to hospital and identified 2,000 cases of bacterial infection.

While in the general population fewer than three in 1,000 children were found to have sickle cell anemia, this figure increased more than 20-fold — to more than 60 per 1,000 — for children admitted to hospital with bacterial infections.

Sickle-cell anemia affects millions of people worldwide, but more than 80 percent of cases are in Africa, where around 200,000 children are born with the disease every year.

It is a genetic disease in which red blood cells deform into a sickle shape and cluster, blocking blood flow and causing pain, vulnerability to infections and organ damage.

The findings confirm that, just as in richer nations, African children with sickle-cell anemia are at huge risk of bacterial infections because the disease hampers blood flow and causes episodes of acute anemia, Williams said.

The most common causes of bacterial infection among children with sickle-cell were Streptococcus pneumoniae (41 percent of cases) and Haemophilus influenzae type b (12 percent of cases).

Vaccines against both — a pneumococcal vaccine and another called Hib — are given routinely in the United States and Europe, but have been slow getting to Africa because funds have largely been focused on other priorities.

Dan Thomas of the Global Alliance for Vaccines and Immunization (GAVI) in Geneva, said his group provides the Hib vaccine, which is made by a range of drug companies, to 35 African nations as part of a 5-in-1 shot.

GAVI has also introduced a pneumococcal vaccine made by Wyeth, a U.S. drug company which is being bought by Pfizer, to Rwanda and Gambia, and is “working on rolling an improved pneumococcal vaccine out across Africa in the next few years,” he said.

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Early daycare may not lower asthma risk

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Early daycare may not lower asthma risk

Contrary to what some previous studies have suggested, children who enter daycare at an early age may not have a reduced risk of allergies and asthma later on, researchers reported Tuesday.

In a study of more than 3,600 children followed from birth, the investigators found that children who entered daycare before the age of 2 were no less likely than their peers to suffer from allergies or asthma at the age of 8.

But early daycare did not appear to raise those risks either, senior researcher Dr. Johan C. de Jongste, of Erasmus University in Rotterdam, the Netherlands, told Reuters Health in an email.

Instead, the findings suggest that daycare has little long-term effect on children’s respiratory health — and that it should not be seen as a way to protect them from allergies and asthma down the road, the researchers report in the journal American Journal of Respiratory and Critical Care Medicine.

The study, de Jongste said, challenges what is known as the “hygiene hypothesis” — the theory that the increasingly germ-free surroundings of modern life are actually contributing to an increase in allergies and asthma.

Some researchers speculate that exposure to viruses and other bugs at daycare may help push a young child’s immune system toward infection-fighting mode, and away from a tendency to over-react to the normally benign substances — the basis of allergic conditions.

Along with daycare attendance, certain other factors that suggest greater early-life exposure to infections — like having older siblings — have also been linked to lower risks of childhood allergies and asthma.

But in the current study, neither daycare nor the presence of older siblings showed long-term effects.

Of the 3,643 children followed from birth to age 8, 30 percent started daycare before age 2. These children were twice as likely as the rest to suffer breathing difficulties in the first year of life.

But the pattern shifted with time, and by the age of 8, early-daycare children were no more — or no less — likely to have episodes of wheezing or other signs or symptoms of asthma. Nor did early daycare affect the risk of showing reactions to airborne allergens during allergy testing.

Children with older siblings were also more likely to have wheezing symptoms in the first year of life, but were no more or no less likely to have signs or symptoms of allergies or asthma at age 8.

The findings, de Jongste’s team writes, suggests that early daycare simply “shifts the burden” of respiratory symptoms to an earlier age, with no tradeoff of protective effects later on.

“Hence,” they conclude, “early daycare should not be promoted for reasons of preventing allergy and asthma.”

SOURCE: American Journal of Respiratory and Critical Care Medicine, September 15, 2009.

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