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Ageing heart can be prevented, say scientists

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Ageing heart can be prevented, say scientists

Scientists in Japan said they have uncovered evidence that shows it may be possible to delay or prevent heart failure in humans.

In a paper published in the journal Circulation, Tetsuo Shioi, lead researcher and assistant professor of medicine at Kyoto University Graduate School of Medicine in Kyoto, and his team described how they managed to suppress a variety of the P13K gene in a group of elderly mice.

The gene regulates the lifespan of cells and plays a role in the aging of tissues. In previous studies, suppression of this gene extended the lifespan of the roundworm and kept the hearts of old fruit flies healthy.

Compared with another group of mice in which the gene was left intact, mice with the suppressed gene had improved cardiac function, less fibrosis (which makes the heart inflexible) and fewer biological markers of aging.

“This study showed that aging of the heart can be prevented by modifying the function of insulin and paves the way to preventing age-associated susceptibility to heart failure,” Shioi said.

Old age is a major risk factor for heart failure, a condition when the heart is unable to pump enough blood around to supply the oxygen the body needs, the World Health Organization says.

According to the American Heart Association, 5.7 million Americans have heart failure, and nearly 10 out of every 1,000 people over age 65 suffer heart failure every year.

Mariell Jessup, professor of medicine at the University of Pennsylvania School of Medicine in Philadelphia, said older people experience a slow but gradual loss of heart cells and a host of other cellular abnormalities which make the remaining cells contract less efficiently.

“This early work in a mouse model, clarifying the role of PI3K in cardiac aging, could ultimately allow scientists to understand if human hearts are similarly influenced,” he said.

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Canada bans fruit-flavored cigarettes

Canada bans fruit-flavored cigarettes

Canada has banned the manufacture, importation and sale of most flavored cigarettes and small cigars, which have been slammed as little more than an enticement to get children to start smoking.

The law, which came into effect on Thursday, was backed by both government and opposition lawmakers. It also bans tobacco advertising in newspapers and magazines, closing a loophole that had allowed ads in publications that claimed they were read only by adults.

Anti-smoking groups said fruit-flavored cigarettes were marketed like candy to lure young smokers, but the industry complained the law was too broad and would unfairly restrict importation of U.S.-grown burley tobacco.

Lawmakers in U.S. tobacco-growing states have complained the law will cost U.S. jobs, and a U.S. Senator has been blocking the appointment of a White House trade official in a bid to make the Obama administration put pressure on Canada.

Anti-smoking groups say the jobs complaint is unfounded since Canada did not import any U.S.-grown burley tobacco in 2007 and 2008, and “American-style” cigarettes make up less than 1 percent of the Canadian market.

“The trade argument was invented out of thin air,” said Rob Cunningham of the Canadian Cancer Society.

The Canadian ban is more sweeping than one imposed last month by the U.S. Food and Drug Administration because it also includes small cigars. Nether ban includes menthol-flavored cigarettes.

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For best healthcare, location matters: study

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For best healthcare, location matters: study

The quality of healthcare Americans receive depends largely on where they live, with insurance coverage, access to preventive medicine and disease treatment varying widely from state to state, according to a study released on Thursday by the Commonwealth Foundation.

“Where you live matters,” said the foundation’s Vice President Cathy Schoen, who co-authored the study for the private research group, in a conference call with reporters. “And it shouldn’t.”

The report found that all of the states that have made healthcare reforms provide better access to medical treatment and prevention and mostly avoid costly hospital procedures.

Residents of Vermont have the best healthcare in the country, the foundation said. The small northern state, which embarked on a radical plan to provide all citizens with healthcare less than a decade ago, also leads the nation in “equity,” or making sure that people of lower income groups have healthcare.

The report comes as the U.S. Congress inches closer to finalizing a plan to reshape healthcare. So far, drafts of the plan have emphasized relying on the states to operate insurance exchanges and possibly to extend more health insurance to families with lower incomes.

“The patterns indicate that public policies, plus state and local health care systems, can make a difference,” according to the report, which was also conducted by Joel Cantor, director of the Center for State Health Policy at Rutgers University.

Hawaii followed Vermont, and Iowa was ranked third on the scorecard. Neither state has a plan to reform healthcare, but Minnesota, which has created public-private collaborations on healthcare, ranks fourth, followed by Maine, which has also implemented sweeping reforms. Massachusetts — the Vermont neighbor that recently began a universal health insurance program — was seventh.

At the other end of the spectrum, Mississippi has the worst healthcare, according to the scorecard. Oklahoma fares mildly better, followed by Louisiana and Arkansas.

Generally, the report found, states in the South, Southwest and lower Midwest have worse insurance rates and less access to good medical treatment.

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