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Breast cancer patients have low vitamin D levels

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Breast cancer patients have low vitamin D levels

In a study of 166 women undergoing treatment for breast cancer, nearly 70 percent had low levels of vitamin D in their blood, according to the study presented at the American Society of Clinical Oncology’s Breast Cancer Symposium in San Francisco.

The analysis showed women with late-stage disease and non-Caucasian women had even lower levels.

“Vitamin D is essential to maintaining bone health, and women with breast cancer have accelerated bone loss due to the nature of hormone therapy and chemotherapy. It’s important for women and their doctors to work together to boost their vitamin D intake,” said Luke Peppone, Ph.D., research assistant professor of Radiation Oncology, at Rochester’s James P. Wilmot Cancer Center.

Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D — 50,000 international units or more — improved the levels, according to Peppone’s study.

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Acupuncture eases tamoxifen-related hot flashes

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Acupuncture eases tamoxifen-related hot flashes

“Acupuncture appears to be at least as effective as drug therapy,” Dr. Eleanor M. Walker of Henry Ford Hospital in Detroit and her colleagues report, “and it may provide additional and longer-term benefits without adverse effects.”

Breast cancer patients with estrogen-sensitive tumors are typically given estrogen-blocking drugs for years at a time. These drugs, which include tamoxifen, bring on menopausal symptoms like hot flashes and night sweats.

The antidepressant drug Effexor (venlafaxine) is the standard treatment for these symptoms, Walker and her team note in the Journal of Clinical Oncology, but it can have unpleasant side effects, including dry mouth, nausea, and constipation. Non-drug treatments with few or no side effects are “urgently needed,” they add.

To investigate whether acupuncture might be an option, Walker and her team randomly assigned 25 women to receive Effexor or acupuncture for 12 weeks, following them for up to year after the end of treatment.

The researchers also point out that Effexor could impair the effectiveness of tamoxifen in some patients, because it can block the body’s metabolism of the drug.

Acupuncture, they conclude, is a “safe, effective and durable treatment” for hot flashes and other menopausal symptoms stemming from anti-estrogen hormone therapy in women with breast cancer. They hope this study will “lead to a change in the pattern of practice” of treating these symptoms in patients with breast cancer.

Eighteen women in the Effexor group had side effects, such as dizziness and anxiety, while none of the women given acupuncture had such side effects. About a quarter of the women given acupuncture said their sex drive had increased. “Most women also reported an improvement in their energy, clarity of thought, and sense of well-being,” Walker and her team note.

The researchers also point out that Effexor could impair the effectiveness of tamoxifen in some patients, because it can block the body’s metabolism of the drug.

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How broccoli can protect your arteries

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How broccoli can protect your arteries

It’s long been thought that broccoli is good for your heart, and now British scientists think they know why.

Researchers at Imperial College London have found evidence a chemical in broccoli and other green leafy vegetables could boost a natural defense mechanism that protects arteries from the clogging that can cause heart attacks.

In a study funded by the British Heart Foundation charity and conducted on mice, the researchers found that sulforaphane — a compound occurring naturally in broccoli and other brassicas — could “switch on” a protective protein which is inactive in parts of the arteries vulnerable to clogging.

“We know that vegetables are clearly good for you, but surprisingly the molecular mechanisms of why they are good for you have remained unknown for many years,” said Paul Evans of the National Heart and Lung Institute at Imperial College.

“This study provides a possible explanation for how green vegetable consumption can promote a healthy heart.”

Scientists already know that arteries don’t clog up in a uniform way, but that there are bends and branches of blood vessels — where blood flow is disrupted or slower — which are much more prone to the build-up of fatty plaques that cause heart disease.

Evans said his research found that in the more vulnerable areas, a normally protective protein known as Nrf2 is inactive.

“What our study showed was that sulforaphane can protect those regions by switching on the Nrf2,” he said.

The research, reported in the journal Arteriosclerosis Thrombosis and Vascular Biology, was conducted using purified sulforaphane, not broccoli. Researchers said the next step was to test the effect of the chemical as it is found in vegetables.

We now need to go and test this with broccoli smoothies, as it were, and compare that with the effect of purified sulforaphane,” Evans said, adding that if the vegetable form proved less effective, there could be an argument for taking sulforaphane in pill form.

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