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Study finds potential way to make an AIDS vaccine

in.reuters.com

Study finds potential way to make an AIDS vaccine

The discovery of immune system particles that attack the AIDS virus may finally open a way to make a vaccine that could protect people against the deadly and incurable infection, U.S. researchers said on Thursday.

They used new technology to troll through the blood of 1,800 people infected with the AIDS virus and identified two immune system compounds called antibodies that could neutralize the virus.

And they found a new part of the virus that the antibodies attack, offering a new way to design a vaccine, they reported in the journal Science.

“So now we may have a better chance of designing a vaccine that will elicit such broadly neutralizing antibodies, which we think are key to successful vaccine development,” said Dennis Burton of The Scripps Research Institute in La Jolla, California, who led the study.

“The findings themselves are an exciting advance toward the goal of an effective AIDS vaccine because now we’ve got a new, potentially better target on HIV to focus our efforts for vaccine design,” added Wayne Koff of the International AIDS Vaccine Initiative, or IAVI, which sponsored the study.

Since the AIDS pandemic started in the early 1980s, more than 25 million people globally have died from the virus. The World Health Organization estimates that 33 million are currently infected.

There is no cure, although a cocktail of drugs can help keep the virus under control. Efforts to make a vaccine have failed almost completely.

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Ethnically dense neighborhood good for health

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Ethnically dense neighborhood good for health

Living in a neighborhood with a lot of people of similar ethnic background may have some health benefit, hints a new study from the United Kingdom.

In the study, fewer activity-limiting long-term illnesses were reported by people who lived in neighborhoods they felt were more than half made up of people with whom they shared a common ethnicity.

This effect was seen among white (primarily of British and Irish ancestry), Indian, Pakistani, Bangladeshi, and African race and ethnic groups, despite the tendency of ethnic minorities to “live in deprived neighborhoods,” Dr. Mai Stafford, from University College London, told Reuters Health in an email correspondence.

Stafford’s team measured actual ethnic density of various neighborhoods and asked residents for their views on the ethnic makeup of their own neighborhood.

The study included 8,850 whites, 1,299 Indians, 678 Pakistanis, 233 Bangladeshis, 690 Africans, and 820 of Caribbean ethnicity.

The investigators found general agreement between actual and perceived ethnic density, except that whites tended to underestimate the proportion of whites in their neighborhoods.

By contrast, “ethnic minority participants tended to overestimate the proportion of people from the same ethnic background as themselves in the local area,” Stafford said.

A health benefit of living in neighborhood with people of the same ethnic background was evident for all ethnic groups – except those of Caribbean ethnicity.

For unexplained reasons that need further study, those of Caribbean ethnicity reported fewer long-term illnesses associated with actual, rather than perceived, ethnic density.

In earlier research, Stafford and colleagues reported ethnic minorities living in areas with greater proportions of “co-ethnics” experience less racial discrimination and associated stress, which may partially explain the current findings.

They call for continued investigations to further explain and clarify the impact neighborhood ethnic density has on overall health.

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