Scientists develop antidote for new class of drugs
A new compound can quickly counteract the action of an emerging class of drugs, offering a way to reverse the drugs’ actions if a patient develops serious side effects, U.S. researchers said on Sunday.
They designed the compound to work with a new blood-thinner being developed for heart patients undergoing angioplasty to clear out blocked arteries.
Such patients need to take blood thinners to prevent blood clots during surgery, but bleeding is a common side effect.
Having an antidote on hand would make the treatments safer, said Bruce Sullenger of Duke University Medical Center, whose study was published in the journal Nature Medicine.
But instead of just reversing the effects of the blood thinner, the antidote agent appears to work against a whole new class of drugs called aptamers.
“Most drugs target proteins. The type of drugs we’re talking about are ribonucleic acids (RNAs) that target proteins,” Sullenger said in a telephone interview.
“Normally in our body we don’t have these types of molecules outside of cells,” Sullenger said.
The antidote agent takes advantage of this, targeting only nucleic acid compounds circulating freely outside the cells.
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