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New survey suggests Americans keen for H1N1 vaccine

New survey suggests Americans keen for H1N1 vaccine

Days before the swine flu vaccine becomes available, more than half of U.S. adults say they will get the vaccine for themselves and 75 percent will get it for their children, according to a survey released on Friday.

Forty percent said they would not get the H1N1 vaccine, the team at the Harvard School of Public Health found.

“These findings suggest that public health officials need to be prepared for a surge in demand for the H1N1 vaccine if the H1N1 flu becomes more severe,” said Harvard’s Robert Blendon, who led the study.

The survey conflicts with one published earlier this week by Consumer Reports showing only 35 percent of Americans would definitely have their children vaccinated.

The Harvard researchers polled 1,042 U.S. adults for what they said was a representative sample of national opinion late last month.

The poll results suggest more people would get a swine flu vaccine than usually get vaccinated against seasonal influenza in the United States, where flu kills an estimated 36,000 mostly elderly people a year.

H1N1 swine flu was declared a pandemic in June and it has circulated globally ever since.

Companies have been rushing to make and distribute vaccines for H1N1 and the U.S. Centers for Disease Control and Prevention says the first 600,000 doses will arrive in cities, states and counties that ordered them next week.

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Experts hope H1N1 will spur effort on universal jab

Experts hope H1N1 will spur effort on universal jab

The H1N1 swine flu pandemic should spur pharmaceutical researchers to renew efforts to develop a universal flu vaccine and rethink ways of dealing with future pandemics, scientists said on Friday.

Flu experts from the World Health Organization, Swiss drug giant Novartis AG, the U.S. National Institutes of Health and others noted that the arrival of H1N1 had prompted a jump in the potential output of vaccine manufacturing to 900 million doses from 400 million.

But in a letter to the journal Science, they urged drug and health industries to be more proactive in developing and distributing vaccines — and in particular to speed up the search for a universal flu vaccine.

“Although the H1N1 pandemic has the potential to cause a social and economic emergency, it also provides an opportunity to rethink our approach to influenza virus disease and to develop more effective vaccines and economically sustainable solutions for developing and developed countries,” they wrote. “Research toward development of a universal vaccine should be accelerated.”

A universal flu vaccine which would combat all strains of the virus has so far eluded pharmaceutical firms and scientists.

Inovio Biomedical Corp, which is working on such a vaccine, said this week that it expects initial evidence early next year on whether the technology it is using can help to fight diseases.

Johnson & Johnson, the world’s biggest diversified health care company, recently bought a stake in Dutch biotech firm Crucell partly to get hold of flu-mAb, a universal antibody engineered to prevent and treat infections from various influenza A strains.

The swine flu outbreak was declared a pandemic in June and has already infected millions of people around the world. Drugmakers and governments have been scrambling to make and supply vaccines targeting the new H1N1 strain before a feared second wave of infection hits as the northern hemisphere heads into winter.

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Cancer drug crosses key hurdle in brain: study

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Cancer drug crosses key hurdle in brain: study

An experimental drug appears to cross a protective barrier in the brain that screens out most chemicals, offering potentially better ways to treat brain tumors, U.S. researchers said on Sunday.

The drug, made by privately held Angiochem Inc of Montreal was safe and showed evidence it could shrink tumors in two separate early phase studies totaling more than 100 people with a brain cancer called glioblastoma.

It also worked among people whose cancers had spread or metastasized to the brain, the researchers reported at the annual meeting of the Society for Neuroscience in Chicago.

In both studies, tumors shrank in patients who got a higher dose of the drug, called ANG1005. The drug also showed signs of working in patients whose cancers resisted the chemotherapy drug taxane.

“It is highly encouraging to see that ANG1005 has shown the potential to be effective in metastatic brain cancers and against drug-resistant tumors,” Dr. Jan Drappatz of Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, who is studying the drug, said in a statement.

Drappatz said tumors shrank significantly in some patients and some neurological problems were reversed in several.

Studies of brain tumor samples showed concentrations of the drug in the tumors, proving it successfully crossed the blood-brain barrier and accumulated.

Made up of a network of blood vessels, the blood-brain barrier prevents 95 percent of all chemicals from leaving the bloodstream and entering the brain.

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