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Experts hope H1N1 will spur effort on universal jab

Experts hope H1N1 will spur effort on universal jab

The H1N1 swine flu pandemic should spur pharmaceutical researchers to renew efforts to develop a universal flu vaccine and rethink ways of dealing with future pandemics, scientists said on Friday.

Flu experts from the World Health Organization, Swiss drug giant Novartis AG, the U.S. National Institutes of Health and others noted that the arrival of H1N1 had prompted a jump in the potential output of vaccine manufacturing to 900 million doses from 400 million.

But in a letter to the journal Science, they urged drug and health industries to be more proactive in developing and distributing vaccines — and in particular to speed up the search for a universal flu vaccine.

“Although the H1N1 pandemic has the potential to cause a social and economic emergency, it also provides an opportunity to rethink our approach to influenza virus disease and to develop more effective vaccines and economically sustainable solutions for developing and developed countries,” they wrote. “Research toward development of a universal vaccine should be accelerated.”

A universal flu vaccine which would combat all strains of the virus has so far eluded pharmaceutical firms and scientists.

Inovio Biomedical Corp, which is working on such a vaccine, said this week that it expects initial evidence early next year on whether the technology it is using can help to fight diseases.

Johnson & Johnson, the world’s biggest diversified health care company, recently bought a stake in Dutch biotech firm Crucell partly to get hold of flu-mAb, a universal antibody engineered to prevent and treat infections from various influenza A strains.

The swine flu outbreak was declared a pandemic in June and has already infected millions of people around the world. Drugmakers and governments have been scrambling to make and supply vaccines targeting the new H1N1 strain before a feared second wave of infection hits as the northern hemisphere heads into winter.

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Run Yoga Run

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Run Yoga Run

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Run Yoga Run

Check out this routine designed to release hamstring, quad, and hip flexor tension. Some knee and shin therapy thrown in for good measure too. If you must run, do some yoga too!

“Yoga is for flexible people. And since I can’t bend like a pretzel I guess that leaves me out.” In fact, tight, inflexible runners and ‘wanna be’ runners stand to gain the most from many of the classical Hatha yoga postures. Although one might think yoga and running are diabolically opposed to one another on the exercise spectrum, the two make an excellent marriage of strength and flexibility.

Yoga’s internal focus will draw your attention to what is going on with your body rather than be externally focused on winning or finishing the race. Runners, and any athlete for that matter, benefit greatly from practicing yoga by building and balancing strength, increasing range of motion, and training the body and mind to work synergistically.

Run Yoga Run is designed from my own experience as a runner and years of practicing yoga. Each week the focus is designed as mini-workshop – working progressively to create greater function in the body from the shoulders and hips to the knees and SI Joints all the while learning to let go of needing to ‘get somewhere’! Yoga is not intended to replace your usual physical training but rather complement it. Improvement comes with time, patience and practice.

Classes are small (maximum 8 students), enabling a free-flow discussion about function, form and alignment. To benefit from the experience, practicing at home is expected. At the end of the 10-week series, you will have learned a yoga sequence that will serve you wherever you are in your athletic endeavours.

Yoga has been lauded by not only runners but athletes around the globe including golfers, cyclists, hockey players, and swimmers, to name a few. These are some of the key benefits for athletes who practice yoga:

Improved range of motion and muscle tone

Increased flexibility, strength and stamina

Reduced stress and tension

Able to ‘lean in’ to challenges with greater ease

An ability to stay focused and balanced

To become more relaxed and refreshed

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Cancer drug crosses key hurdle in brain: study

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Cancer drug crosses key hurdle in brain: study

An experimental drug appears to cross a protective barrier in the brain that screens out most chemicals, offering potentially better ways to treat brain tumors, U.S. researchers said on Sunday.

The drug, made by privately held Angiochem Inc of Montreal was safe and showed evidence it could shrink tumors in two separate early phase studies totaling more than 100 people with a brain cancer called glioblastoma.

It also worked among people whose cancers had spread or metastasized to the brain, the researchers reported at the annual meeting of the Society for Neuroscience in Chicago.

In both studies, tumors shrank in patients who got a higher dose of the drug, called ANG1005. The drug also showed signs of working in patients whose cancers resisted the chemotherapy drug taxane.

“It is highly encouraging to see that ANG1005 has shown the potential to be effective in metastatic brain cancers and against drug-resistant tumors,” Dr. Jan Drappatz of Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, who is studying the drug, said in a statement.

Drappatz said tumors shrank significantly in some patients and some neurological problems were reversed in several.

Studies of brain tumor samples showed concentrations of the drug in the tumors, proving it successfully crossed the blood-brain barrier and accumulated.

Made up of a network of blood vessels, the blood-brain barrier prevents 95 percent of all chemicals from leaving the bloodstream and entering the brain.

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