Tag Archives: health history

Stem cell transplants stalled blindness in rats

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Stem cell transplants stalled blindness in rats

Nerve stem cell transplants may help slow the progression of macular degeneration, the most common cause of blindness in the developed world, U.S. researchers said on Monday.

They said putting nerve stem cells from StemCells Inc near the retinas of rats with a form of macular degeneration helped keep the disease from advancing to blindness for several months.

“These cells improve the chemical environment in the back of the eye,” said Ray Lund of the Casey Eye Institute at Oregon Health & Science University in Portland, whose findings were presented at the Society for Neuroscience meeting in Chicago.

Lund said the mechanism is not clear, but he suspects that when immature nerve cells are placed near the retina, they produce growth factors that protect the cells from damage by the disease.

“It’s basically a chemical pump that is sitting in the right place and producing the right things,” Lund said in a telephone interview.

Where normally animals with eye disease lost their vision by three months old, rats that got the transplants kept their vision for at least seven months, he said.

“There is no evidence that they (the transplanted cells) do any damage,” Lund said, adding that the animals do not develop tumors, a key worry for stem cell transplants.

The findings raise hope for use of the treatment in humans with a range of diseases in which the retina become damaged, including age-related macular degeneration or AMD, which affects nearly 30 million people worldwide, including 15 million Americans.

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Teeth Whitening : Can Baking Powder Bleach Your Teeth?

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Teeth Whitening : Can Baking Powder Bleach Your Teeth?

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Baking powder can bleach teeth because it contains baking soda. Simply create a paste of one-part baking powder to one-part water, and brush for one-to-two minutes.

Whiten teeth with baking powder, making sure to rinse thoroughly after brushing, with tips from a licensed dental assistant in this free video on oral hygiene.

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Long-term monkey tests back Oxford’s gene therapy

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Long-term monkey tests back Oxford’s gene therapy

Long-term tests on monkeys using Oxford BioMedica’s gene therapy ProSavin suggest it can treat Parkinson’s disease without causing the jerky, involuntary movements associated with current drugs, researchers said on Wednesday.

Parkinson’s is caused by lack of the brain chemical dopamine. Standard treatment involves oral drugs that briefly raise dopamine levels — but levels of the chemical still remain unstable, leading to a movement disorder called dyskinesias.

By contrast, tests on macaque monkeys found the gene therapy safely restored concentrations of dopamine in the brain, corrected motor deficits and prevented dyskinesias — with no severe adverse side effects.

French researchers observed the animals for up to three and a half years in the study, after first inducing Parkinsonian syndrome by giving a neurotoxin and then treating them with gene therapy injections.

“Gene therapy-mediated dopamine replacement may be able to correct Parkinsonism in patients without the complications of dyskinesias,” Bechir Jarraya and colleagues wrote in the journal Science Translational Medicine.

Oxford BioMedica is currently conducting Phase I/II clinical trials with ProSavin and in July announced encouraging initial results.

ProSavin, which is administered directly to the striatum in the brain, delivers three genes required to convert cells that normally do not produce dopamine into cells that do.

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