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Arena weight-loss data expected to underwhelm

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Arena weight-loss data expected to underwhelm

Upcoming trial results for lorcaserin, the experimental obesity drug being developed by Arena Pharmaceuticals Inc, will likely show it is about 4 percentage points more effective in promoting weight loss than a dummy pill

But that is well short of the 9.4 percent placebo-adjusted weight loss reported last week by Vivus Inc, which is developing Qnexa — a combination of phentermine and epilepsy treatment topiramate, both now sold as generics, that is designed to minimize side effects from the two drugs.

But Wall Street is not discounting the value of a viable treatment for obesity, a health-damaging condition afflicting more than one-quarter of all Americans. “Right now physicians have pretty much nothing,” said JMP Securities analyst Jason Butler.

Piper Jaffray has forecast lorcaserin sales of $3 billion in 2015.

One-year results from Vivus’ Qnexa trials sent the company’s stock up more than 70 percent on Wednesday.

“There is a lot less opportunity for that to happen with this (Arena) trial,” Butler said. “We’ve seen so much data already.”

Shares of Arena, which ended Nasdaq trading at $5.30 on Friday, closed as low as $2.26 in April and as high as $7.42 in February.

The phentermine used in Vivus’ Qnexa is a stimulant that was part of the fen-phen diet drug cocktail. Other drugs used in the cocktail, flenfluramine and dexfenfluramine, were recalled in 1997 after they were linked to heart valve damage.

SIDESTEPS HEART PROBLEMS

Lorcaserin is a serotonin activator like fenfluramine, but it is designed to selectively target only one variety of the chemical — and thereby sidestep heart-related side effects.

Earlier studies have found no heart problems associated with the drug. “There is no reason to expect anything different safety-wise,” from the new trial results expected this month, said Carol Werther, an analyst at Summer Street Research.

The company earlier this year said a large, year-long trial found that lorcaserin patients, on average, lost 5.8 percent of their body weight, while placebo patients lost 2.2 percent of their weight — a percentage point difference of 3.6 percent.

“No single agent has consistently shown a 5 percentage point difference,” said Werther.

U.S. Food and Drug Administration guidelines for obesity drugs require a 5 percent improvement in weight loss between the test drug and placebo or that the number of subjects who lose at least 5 percent of their body weight be at least 35 percent, and double the proportion in the placebo group, with a statistically significant difference between the groups.

The earlier lorcaserin trial found that 48 percent of patients on the drug lost 5 percent or more of their weight, while 20.3 percent of placebo patients achieved that goal

Dominic Behan, chief scientific officer and co-founder of Arena, said a major advantage of lorcaserin is that it is a single agent, and that doctors do not need to adjust doses for patients.

Moreover, he said lorcaserin improved cholesterol levels in patients. And data from earlier trials suggest it can be safely taken on a chronic basis, Behan said. By contrast, he said phentermine is currently approved only for short-term use.

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Weight Loss Exercise Program Week 1

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Weight Loss Exercise Program Week 1

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earn how to lose weight with our weight loss exercise routine program.

Follow this workout with week 2 for a progressive workout plan to lose the maximum amount of weight.

oin our weight loss challenge and watch your body get slim and sexy. Each week, the exercise routine will get increasingly difficult. Start with Week 1 and progress when you are ready.

Perform this routine 2x a week on nonconsecutive days.

Balance on 1 leg throughout the whole set
Keep your weight back towards your heels
Always sit back into your hips
Maintain a flat/neutral spine
Keep your chest up
Breathe in on the way down and out on the way up

There are many different variations to this exercise, but I recommend beginners start by sitting back onto a chair or box. You can then progress by getting deeper and deeper each set or week. When you become advanced you can eventually stop using any supportive box behind you and do them free standing.

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Fat Removal Surgery

Fat Removal Surgery

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Obesity is a condition in which the natural energy reserve, stored in the fatty tissue of humans and other mammals, is increased to a point where it is associated with certain health conditions or increased mortality.

Fat Removal Surgery Procedures

Buccal Fat Removal

This is a cosmetic surgery procedure that is designed to remove the fat pads in the lower cheeks as a remedy for what is known as chipmunk cheeks. You are given a choice of preference in anaesthesia as advised by your cosmetic surgeon and can expect the operation to last 1-1.5 hours. Full recovery is usually attainable within three weeks, but it is advised to take plenty of rest for up to two weeks after the operation.

LipoSelection: Ultrasonic-Assisted Liposuction – Vaser

LipoSelection only by Vaser is a revolutionary new body-shaping cosmetic surgery procedure directly targeting only the fat cells you yourself wish to be removed. With this amazing ultrasonic-assisted system, you will be experiencing the most advanced fat removal surgery technology available. It is a gentle process, the procedure carefully dissolving fat in areas of the body including the abdomen, thighs, neck and arms. This can take 1-3 hours under local anaesthetic, entirely dependent on the volume of fat to be removed and from where. Another benefit of this procedure is that recovery is generally much faster than with any other fat removal surgery.

Liposuction

One of the most popular cosmetic surgery procedures of all that are available, Liposuction is a fat removal procedure that aims to eradicate excessive stubborn fat from areas of the body including the chin, chest, back, stomach, and thighs. Depending on the finer details of your chosen Liposuction procedure, each session takes 1-1.5 hours and it is possible you could return home the same day – although some patients either prefer or are advised to remain in the clinic for one or two days after the Liposuction has taken place.

Obesity weight loss surgery

Obesity surgery is a surgical procedure for people who have tried everything to lose weight but have not been able to lose weight or maintain weight loss. In the UK it is estimated that 20% of men and 25% of women are obese and nearly half the population are over their ideal weight.

Abdominoplasty (Tummy Tuck)

This is another very popular cosmetic surgery procedure, focused on the removal of fat and excess skin from around the waist that cannot be eliminated through diet and exercise. The results of Tummy Tuck surgery are often extraordinary, but please keep your expectations realistic, as you should with any cosmetic surgical procedure. It takes just 1-2 hours to perform this procedure and you can expect to stay in the cosmetic surgery clinic for either one or two nights.

Mini Tummy Tuck

The Mini Tummy Tuck cosmetic surgery procedure is similar to the Abdominoplasty, but does not involve repositioning of the navel as in the full Tummy Tuck operation. (Please see the Tummy Tuck page for full details of the surgical procedure). It is identical, though, in that its intention is to remove excess fatty tissue and skin from the stomach and waist. This operation takes 1-2 hours and is likely to need an overnight stay to begin your After Care plan.

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