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Experts hope H1N1 will spur effort on universal jab

Experts hope H1N1 will spur effort on universal jab

The H1N1 swine flu pandemic should spur pharmaceutical researchers to renew efforts to develop a universal flu vaccine and rethink ways of dealing with future pandemics, scientists said on Friday.

Flu experts from the World Health Organization, Swiss drug giant Novartis AG, the U.S. National Institutes of Health and others noted that the arrival of H1N1 had prompted a jump in the potential output of vaccine manufacturing to 900 million doses from 400 million.

But in a letter to the journal Science, they urged drug and health industries to be more proactive in developing and distributing vaccines — and in particular to speed up the search for a universal flu vaccine.

“Although the H1N1 pandemic has the potential to cause a social and economic emergency, it also provides an opportunity to rethink our approach to influenza virus disease and to develop more effective vaccines and economically sustainable solutions for developing and developed countries,” they wrote. “Research toward development of a universal vaccine should be accelerated.”

A universal flu vaccine which would combat all strains of the virus has so far eluded pharmaceutical firms and scientists.

Inovio Biomedical Corp, which is working on such a vaccine, said this week that it expects initial evidence early next year on whether the technology it is using can help to fight diseases.

Johnson & Johnson, the world’s biggest diversified health care company, recently bought a stake in Dutch biotech firm Crucell partly to get hold of flu-mAb, a universal antibody engineered to prevent and treat infections from various influenza A strains.

The swine flu outbreak was declared a pandemic in June and has already infected millions of people around the world. Drugmakers and governments have been scrambling to make and supply vaccines targeting the new H1N1 strain before a feared second wave of infection hits as the northern hemisphere heads into winter.

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Cancer, bowel drugs on FDA safety scrutiny list

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Cancer, bowel drugs on FDA safety scrutiny list

More than a dozen drugs including a cancer therapy and a bowel medicine are under early scrutiny for potential side effects, U.S. regulators said in a quarterly list released on Thursday.

The Food and Drug Administration said it was investigating cases of liver failure in patients treated with Pfizer Inc’s cancer drug Sutent. The agency also is reviewing gastrointestinal perforation reported with Relistor, a drug from Wyeth and Progenics Pharmaceuticals for treating opioid-induced constipation.

Appearing on the list “means that FDA has identified a potential safety issue, but does not mean that FDA has identified a causal relationship between the drug and the listed risk,” the agency said.

The FDA releases a quarterly list of safety probes as part of an effort to inform the public about early investigations of potential side effects that have been reported. The list released on Thursday covers issues identified between January and March 2009.

Pfizer said in a statement it would “work with the FDA to assess the reports (on Sutent) and determine a path forward.”

In clinical trials, liver failure was seen in less than 1 percent of patients with solid tumors who were treated with Sutent, the company said.

“We stand behind the safety and efficacy of Sutent,” Pfizer said. The drug is approved for treating advanced kidney cancer and a digestive cancer known as gastrointestinal stromal tumor.

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FLEXability

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Why?
Stretching your muscles is good preparation for all types of sports and fitness; it helps prevent injury for people who exercise intensely, or, on the flipside, for people whose muscles are stiff. By fitting out the stretching area in your club with equipment featuring cutting-edge technology, you’ll open new horizons for your business, relaunching an activity that has the potential for a very broad user spectrum.

The FLEXability™ Line is Anterior and Posterior, two pieces of equipment that together stretch all the body’s main muscle groups, designed to achieve maximum performance for minimum effort in every exercise.

Users can adjust FLEXability™ entirely on their own; it’s designed for total comfort, revolutionizing the stretching experience and transforming it into a pleasant new form of exercise.

Who’s it for?
Athletes who want to prevent strains and other injury and reduce the muscle tension caused by intense, targeted workouts.

For mature exercisers, who want to maintain and, where possible, improve the elasticity and flexibility of their joints and the efficiency of their muscles.

For people who want to relax with a pleasant exercise that’s non-invasive but still produces results for your physical condition.

For newcomers to physical activity, in order to increase their ability to move and help get themselves into a more active lifestyle: the more movement they’re able to do, the easier it will be to tackle all the other options available in your club.

Stretching your muscles doesn’t require specific training, and that’s even more true with FLEXability™: thanks to its Method (dynamic, innovative, and patented), the line makes it possible to gradually adjust the stretching range based on your weight, preventing any risk under any condition and for any user.

And for people who want that extra incentive?
FLEXability™ is designed for that too: thanks to an assessment and feedback system on reachable results, the equipment measures the progress of your flexibility, motivating all types of users to improve their mobility and muscle extension day after day.

Choose flexibility: with FLEXability™, traditional stretching takes on a new face, becoming a high-performance activity that’s engaging for every user segment.