Tag Archives: million

Prostate cancer screening: More harm than good?

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Prostate cancer screening: More harm than good?

One meaning of screening is the investigation of a great number of something (for instance, people) looking for those with a particular problem or feature. For example at an airport many bags are screened by x-ray to try to detect any which may contain weapons or explosives, and people are screened by passing through a metal detector. If only part of a population is screened, screening is equivalent to sampling in statistics.

Screening can also mean preventing access of something by some sort of barrier. Particular cases:

Electromagnetic shielding in physics, the exclusion of electric, magnetic, or electromagnetic fields by a metallic screen or shield

In atomic physics and chemistry, the screening effect or atomic shielding is the reduction of effective nuclearcharge by intervening electron shells

Screening (printing), a process that represents lighter shades as tiny dots, rather than solid areas, of ink by passing ink through a perforated screen

The investigation of a large population is related; the members of a population are filtered by a metaphorical, rather than physical, screen

Screening is a process stage when cleaning paper pulp

Routine screening for prostate cancer has resulted in more than 1 million U.S. men being diagnosed with tumors who might otherwise have suffered no ill effects from them, U.S. researchers said on Monday.

They said prostate cancer screening is a double-edged sword, catching serious cancers in a few but causing needless worry and expense for the majority of men, who may be getting treatment for tumors growing too slowly to do any harm.

The team looked to see how many additional men have been diagnosed with prostate cancer since the introduction in 1986 of a widely used blood test for prostate cancer that looked for a prostate-cancer specific antigen, or PSA.

“Our estimate is that number is about 1.3 million people in the United States. That is a huge effect,” said Dr. H. Gilbert Welch of the VA Outcomes Group in White River Junction, Vermont, whose study appears in the Journal of the National Cancer Institute.

More than 1 million of those were treated, they found.

“These are men who could not be helped by treatment because their cancer was not destined to cause them symptoms or death,” Welch said in a telephone interview.

The increased diagnosis rate more than tripled in men aged 50 to 59 and increased more than a sevenfold in men under age 50.

And while prostate cancer deaths have declined since the introduction of PSA testing, Welch said about 20 men had to be diagnosed and treated for every one who benefited.

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Swine flu vaccination effort starts Monday: CDC

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Swine flu vaccination effort starts Monday: CDC

Healthcare workers in Indiana and Tennessee will be among the first to get swine flu vaccines in the United States on Monday, the U.S. Centers for Disease Control and Prevention said.

Vaccination clinics are scheduled for Monday morning for staff at Le Bonheur Children’s Medical Center in Memphis, Tennessee and Wishard Health Services in Indianapolis, the CDC said.

Last week, the center said the first doses of H1N1 swine flu vaccine would arrive on Tuesday. The first vaccines to administered will be AstraZeneca unit MedImmune’s nasal spray.

The U.S. government has ordered about 250 million doses from five companies — Sanofi-Aventis SA, CSL Ltd MedImmune, Novartis AG and GlaxoSmithKline. MedImmune had especially good production of the H1N1 vaccine and has been the first to make doses available.

The vaccines will trickle in at a rate of about 20 million doses a week, and officials are unsure how many Americans will actually get them. The U.S. government is providing them for free,

but clinics and retailers may charge to administer them.

The picture is further complicated by seasonal flu vaccination, which started last month.

Pandemic H1N1 has been circulating since it was first identified in two U.S. children last March but it has picked up speed since schools returned from their summer break in August.

The CDC said it is not especially deadly, but it is affecting younger people than seasonal flu usually does and at a time of year when there is generally little or no influenza.

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Experts hope H1N1 will spur effort on universal jab

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Experts hope H1N1 will spur effort on universal jab

The H1N1 swine flu pandemic should spur pharmaceutical researchers to renew efforts to develop a universal flu vaccine and rethink ways of dealing with future pandemics, scientists said on Friday.

Flu experts from the World Health Organization, Swiss drug giant Novartis AG, the U.S. National Institutes of Health and others noted that the arrival of H1N1 had prompted a jump in the potential output of vaccine manufacturing to 900 million doses from 400 million.

But in a letter to the journal Science, they urged drug and health industries to be more proactive in developing and distributing vaccines — and in particular to speed up the search for a universal flu vaccine.

“Although the H1N1 pandemic has the potential to cause a social and economic emergency, it also provides an opportunity to rethink our approach to influenza virus disease and to develop more effective vaccines and economically sustainable solutions for developing and developed countries,” they wrote. “Research toward development of a universal vaccine should be accelerated.”

A universal flu vaccine which would combat all strains of the virus has so far eluded pharmaceutical firms and scientists.

Inovio Biomedical Corp, which is working on such a vaccine, said this week that it expects initial evidence early next year on whether the technology it is using can help to fight diseases.

Johnson & Johnson, the world’s biggest diversified health care company, recently bought a stake in Dutch biotech firm Crucell partly to get hold of flu-mAb, a universal antibody engineered to prevent and treat infections from various influenza A strains.

The swine flu outbreak was declared a pandemic in June and has already infected millions of people around the world. Drugmakers and governments have been scrambling to make and supply vaccines targeting the new H1N1 strain before a feared second wave of infection hits as the northern hemisphere heads into winter.

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